Polysensitization and increased susceptibility in contact allergy: a review

Allergy
A SchnuchW Uter

Abstract

Genetic factors presumably play a role in contact allergy (CA). There is, however, a lack of conclusive evidence from clinical studies. This may be on account of the strongly competing or modifying impact of exogenous factors, namely the potency of allergens and the intensity of exposure, and the fact that - in principle - everybody can be sensitized. Regarding phenotype, in contrast, polysensitization (PS) seems to indicate a subset of individuals at greater risk. In human sensitization experiments with dinitrochlorobenzene, induction was facilitated in PS, and elicitation enhanced. Recent clinical epidemiological data, taking confounders for PS, such as age, sex, and other skin diseases into account, demonstrated the following: (i) PS was the greatest risk factor to be sensitized to a number of (even weak) index allergens, indicating higher susceptibility on the level of induction; (ii) patch test reactions in PS patients were generally stronger indicating higher susceptibility on the level of elicitation. These findings are complemented by reports on polymorphisms of TNF-alpha and IL-16 in PS patients. Future studies on the genetics of CA should be performed in subgroups with PS, focussing on polymorphisms relevant for CA-sp...Continue Reading

References

Aug 1, 1975·Contact Dermatitis·J C Mitchell
Jan 1, 1992·Dermatology : International Journal for Clinical and Investigative Dermatology·F Pasche-Koo, C Hauser
Mar 1, 1991·Contact Dermatitis·R ValsecchiP D Pigatto
Mar 1, 1991·Clinical and Experimental Dermatology·P S Friedmann
Feb 1, 1991·Contact Dermatitis·B Edman
Sep 1, 1990·Clinical and Experimental Immunology·P S FriedmannJ N Matthews
Dec 1, 1989·Journal of the American Academy of Dermatology·R GollhausenJ Ring
Aug 1, 1986·The British Journal of Dermatology·A Kligman, R Gollhausen
Jan 1, 1967·International Archives of Allergy and Applied Immunology·F B WalkerH I Maibach
Jan 1, 1983·Archives of Dermatological Research·D P BruynzeelW G van Ketel
Mar 1, 1983·Journal of the American Academy of Dermatology·D P BruynzeelR J Scheper
Jan 1, 1981·Contact Dermatitis·H J Bandmann, M Agathos
Nov 1, 1995·Contact Dermatitis·C Kwangsukstith, H I Maibach
Feb 1, 1996·The British Journal of Dermatology·A A Memon, P S Friedmann
Mar 1, 1996·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·I DuarteN G Proença
Dec 1, 1996·The British Journal of Dermatology·A A Memon, P S Friedmann
Feb 1, 1997·Contact Dermatitis·A KatsarouM Papamihail
Oct 23, 1997·Contact Dermatitis·K KalimoT Niskanen
Mar 11, 1999·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·T AgnerT Menné
Jun 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A KatsarouS Georgala
Jun 5, 1999·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·M HindsénO B Christensen
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·T SchäferH E Wichmann
Dec 26, 2001·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·J BraschUNKNOWN German Contact Dermatitis Research Group and the Information Network of Departments of Dermatology in Germany
Feb 16, 2002·Contact Dermatitis·N H NielsenT Jørgensen
Jun 22, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Wolfgang UterIsaak Effendy
Sep 5, 2002·The British Journal of Dermatology·I KimberC E M Griffiths
Dec 21, 2002·Contact Dermatitis·M Isaksson
Apr 16, 2003·Contact Dermatitis·Götz A WestphalKristian Reich
Feb 1, 1958·A.M.A. Archives of Dermatology·A M KLIGMAN
Sep 27, 2003·The British Journal of Dermatology·R SkoetT Agner
Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I KimberH-W Vohr
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Kristian ReichAxel Schnuch
Jan 28, 2004·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·Heinrich DickelThomas M Bruckner
Dec 21, 2004·The British Journal of Dermatology·J ElberlingJ D Johansen

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Citations

Feb 21, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U Ayazpoor
Sep 10, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Schnuch
May 11, 2012·International Archives of Allergy and Immunology·Franziska RuëffThomas Herzinger
Jun 12, 2009·Cutaneous and Ocular Toxicology·David A Basketter
Oct 17, 2009·Industrial Health·Sanja KezicMaarten M Verberk
Apr 18, 2012·Clinics in Dermatology·Ehrhardt Proksch, Jochen Brasch
Feb 12, 2009·The Journal of Investigative Dermatology·Sara J Brown, W H Irwin McLean
Aug 12, 2009·The British Journal of Dermatology·B C CarlsenJ D Johansen
Aug 8, 2009·Contact Dermatitis·Berit Christina CarlsenJeanne Duus Johansen
May 31, 2008·The British Journal of Dermatology·A SchnuchW Uter
Jul 23, 2013·Contact Dermatitis·Wolfgang UterOlaf Gefeller
May 8, 2013·The British Journal of Dermatology·J SchwitullaW Uter
Oct 16, 2010·Contact Dermatitis·Anja Pahlow MoseKlaus Ejner Andersen
Dec 21, 2010·Contact Dermatitis·Axel SchnuchKristian Reich
May 15, 2012·Contact Dermatitis·Francesca RuiFrancesca Larese Filon
Mar 23, 2012·Contact Dermatitis·Mariette J C NagtegaalThomas Rustemeyer
Sep 24, 2009·The British Journal of Dermatology·A SchnuchR A Jörres
May 4, 2010·Contact Dermatitis·Francesca RuiFrancesca Larese Filon
Nov 13, 2013·Contact Dermatitis·Verena G HerbertKristine Breuer
Jun 25, 2015·Contact Dermatitis·David BregnbakJacob P Thyssen
Sep 5, 2013·Allergy, Asthma & Immunology Research·Inseon S ChoiJoon Jin
Apr 2, 2010·Allergy, Asthma & Immunology Research·Inseon S ChoiYoung-Ho Won
Mar 17, 2015·Journal of Cutaneous Medicine and Surgery·Kathleen Fraser, Melanie Pratt
Oct 27, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·F ZulianiF Larese Filon
May 13, 2017·Contact Dermatitis·Sjors A KoppesJacob P Thyssen
Mar 17, 2017·Contact Dermatitis·Daan Dittmar, Marie L Schuttelaar
Feb 23, 2018·Contact Dermatitis·Daan DittmarUNKNOWN ESSCA Network
Nov 30, 2018·Contact Dermatitis·Waranaree Winayanuwattikun, Waranya Boonchai
Jan 10, 2019·Contact Dermatitis·Haudrey AssierOlivier Chosidow
Jun 11, 2016·The British Journal of Dermatology·M D LynchP Banerjee
Oct 2, 2021·Contact Dermatitis·Sheila M McSweeneyJohn A McGrath

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