PMID: 11932940Apr 5, 2002Paper

Polysialic acid and the formation of oculomotor synapses on chick ciliary neurons

The Journal of Comparative Neurology
Juan L BrusésUrs Rutishauser

Abstract

The polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) participates in a variety of developmental processes, including axonal guidance and cell migration. PSA's function in these contexts stems from its ability to reduce cell interactions. The present study examines the regulation of PSA expression during formation of the calyciform synapse by the oculomotor axons on chick ciliary neurons. Prior to synaptogenesis, PSA is abundantly and uniformly expressed on the surface of the ciliary neuron body. However, at the time synaptic bonds start to form, as reflected in the localized accumulation of synaptic vesicles, PSA is lost from the point of synaptic contact. Thereafter, PSA is progressively lost from the ciliary neuron surface as the calyx grows. The dense mats of pseudodendritic-like somatic spines, which extend from the postsynaptic cell body, form an exception. These spines, which are known to undergo morphological remodeling, retain PSA expression until the end of embryogenesis. The experimental removal of PSA did not affect synaptogenesis itself, in that no significant changes were observed in the surface covered by the calyx, the number of spine aggregates, the size of acetylcholine receptor clusters...Continue Reading

References

Nov 1, 1978·The Journal of Physiology·L Landmesser
Jul 1, 1991·The Journal of Cell Biology·A AchesonU Rutishauser
May 1, 1972·The Journal of Physiology·L Landmesser, G Pilar
Sep 1, 1974·The Journal of Physiology·L Landmesser, G Pilar
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M H JacobJ M Lindstrom
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D BertrandJ P Changeux
Feb 1, 1960·The Journal of Biophysical and Biochemical Cytology·A J DE LORENZO
Jan 27, 1964·Acta Neurovegetativa·J SZENTAGOTHAI
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Citations

Oct 2, 2003·Current Opinion in Cell Biology·Masahito YamagataJoshua A Weiner
May 22, 2010·Tissue Engineering. Part a·Kirsten Haastert-TaliniClaudia Grothe
Mar 11, 2003·Annual Review of Neuroscience·Peter Scheiffele
Jan 24, 2009·Molecular and Cellular Neurosciences·Glen S MarrsJuan L Brusés
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti
Feb 14, 2006·Neurochemistry International·Ralph SeidenfadenHerbert Hildebrandt
Sep 11, 2012·European Journal of Pharmacology·Ana DjordjevicMarija B Radojcic
Oct 25, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ana DjordjevicMarija B Radojcic
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Athanasios K PetridisUrs Rutishauser
Dec 7, 2007·Nature Reviews. Neuroscience·Urs Rutishauser
Apr 18, 2009·Cell Adhesion & Migration·Luca Bonfanti, Dionysia T Theodosis

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