Abstract
The polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) participates in a variety of developmental processes, including axonal guidance and cell migration. PSA's function in these contexts stems from its ability to reduce cell interactions. The present study examines the regulation of PSA expression during formation of the calyciform synapse by the oculomotor axons on chick ciliary neurons. Prior to synaptogenesis, PSA is abundantly and uniformly expressed on the surface of the ciliary neuron body. However, at the time synaptic bonds start to form, as reflected in the localized accumulation of synaptic vesicles, PSA is lost from the point of synaptic contact. Thereafter, PSA is progressively lost from the ciliary neuron surface as the calyx grows. The dense mats of pseudodendritic-like somatic spines, which extend from the postsynaptic cell body, form an exception. These spines, which are known to undergo morphological remodeling, retain PSA expression until the end of embryogenesis. The experimental removal of PSA did not affect synaptogenesis itself, in that no significant changes were observed in the surface covered by the calyx, the number of spine aggregates, the size of acetylcholine receptor clusters...Continue Reading
References
Nov 1, 1978·The Journal of Physiology·L Landmesser
Jun 1, 1992·Neuron·J TangU Rutishauser
Sep 4, 1992·Cell·M B FeanyK M Buckley
Dec 1, 1990·Neuron·S CouturierM Ballivet
Jan 1, 1991·Anatomy and Embryology·T Seki, Y Arai
Jul 1, 1991·The Journal of Cell Biology·A AchesonU Rutishauser
May 1, 1990·Neuron·L LandmesserU Rutishauser
Nov 1, 1986·The Journal of Cell Biology·M WatanabeU Rutishauser
Apr 1, 1985·The Journal of Cell Biology·K Buckley, R B Kelly
Apr 1, 1988·Science·U RutishauserJ Sunshine
Jan 22, 1971·Brain Research·R MarwittJ N Weakly
May 1, 1972·The Journal of Physiology·L Landmesser, G Pilar
Sep 1, 1974·The Journal of Physiology·L Landmesser, G Pilar
Jun 1, 1965·The Journal of Cell Biology·A Hess
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M H JacobJ M Lindstrom
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D BertrandJ P Changeux
Sep 1, 1994·Neuron·K OnoU Rutishauser
Aug 1, 1994·Neuron·J TangL Landmesser
Sep 1, 1993·Neuroscience Research·T Seki, Y Arai
Mar 1, 1996·The Journal of Cell Biology·V F Rafuse, L Landmesser
Sep 1, 1996·Neuron·D MullerJ Z Kiss
Oct 1, 1996·Trends in Neurosciences·U Rutishauser, L Landmesser
Dec 1, 1996·The Journal of Cell Biology·C WangJ Z Kiss
Dec 1, 1996·Neuron·Z W ZhangD K Berg
Jun 1, 1997·Neuron·M E Rubio, R J Wenthold
Apr 18, 1998·The Journal of Cell Biology·J L Brusés, U Rutishauser
Apr 10, 1999·Nature Neuroscience·B M WilliamsM H Jacob
Jun 27, 2001·The Journal of Biological Chemistry·I FujimotoU Rutishauser
Feb 1, 1960·The Journal of Biophysical and Biochemical Cytology·A J DE LORENZO
Jan 27, 1964·Acta Neurovegetativa·J SZENTAGOTHAI
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON
Citations
Oct 2, 2003·Current Opinion in Cell Biology·Masahito YamagataJoshua A Weiner
May 22, 2010·Tissue Engineering. Part a·Kirsten Haastert-TaliniClaudia Grothe
Mar 11, 2003·Annual Review of Neuroscience·Peter Scheiffele
Jan 24, 2009·Molecular and Cellular Neurosciences·Glen S MarrsJuan L Brusés
Jul 31, 2007·Brain Research Reviews·Eduardo GasconJozsef Zoltan Kiss
Mar 3, 2007·Experimental Neurology·N D T ZinckJ W Downie
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti
Feb 14, 2006·Neurochemistry International·Ralph SeidenfadenHerbert Hildebrandt
Sep 11, 2012·European Journal of Pharmacology·Ana DjordjevicMarija B Radojcic
Oct 25, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ana DjordjevicMarija B Radojcic
Dec 17, 2009·Journal of Pediatric Surgery·Katsumi MiyaharaAtsuyuki Yamataka
Oct 4, 2005·Progress in Brain Research·Natasha D T Zinck, John W Downie
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Athanasios K PetridisUrs Rutishauser
Dec 7, 2007·Nature Reviews. Neuroscience·Urs Rutishauser
Apr 3, 2014·Physiological Reviews·Ronald L SchnaarHerbert Hildebrandt
Apr 18, 2009·Cell Adhesion & Migration·Luca Bonfanti, Dionysia T Theodosis