Poly(silsesquioxanes) and poly(siloxanes) grafted with N-acetylcysteine for eradicating mature bacterial biofilms in water environment

Colloids and Surfaces. B, Biointerfaces
Maria NowackaAnna Kowalewska

Abstract

Bacteria adapt to their living environment forming organised biofilms. The survival strategy makes them more resistant to disinfectants, which results in acute biofilm-caused infections, secondary water pollution by biofilm metabolites and bio-corrosion. New, efficient and environmentally friendly strategies must be developed to solve this problem. Water soluble N-acetyl derivative of L-cysteine (NAC) is a non-toxic compound of mucolytic and bacteriostatic properties that can interfere with the formation of biofilms. However, it can also be a source of C and N for undesired microorganisms, as well as a reason for some adverse human health effects. Consequently, novel procedures are required, that would decrease the take-up of NAC but not reduce its antibacterial properties. We have grafted N-acetyl-l-cysteine onto linear poly(vinylsilsesquioxanes) and poly(methylvinylsiloxanes) via thiol-ene addition. Antibacterial activity of the obtained hybrid materials (respectively, NAC-Si-1 and NAC-Si-2) was determined against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus strains. Native NAC inhibited growth of planktonic cells for the tested bacteria at concentration 0.25% w/v. Inhibition with equivalent solutions of...Continue Reading

Citations

Sep 6, 2020·International Journal of Molecular Sciences·Karolina GloszTomasz Jarosz
Apr 27, 2019·International Journal of Molecular Sciences·Dorota KregielAnna Kowalewska
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria NowackaAnna Kowalewska
Mar 3, 2021·Environmental Science and Pollution Research International·Lola Virág KissPéter István Nagy
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vlad CozmaCarmen Racles

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