PMID: 4287165Jul 1, 1966Paper

Polysomes and protein synthesis in cells infected with a DNA virus

Science
R J Sydiskis, B Roizman

Abstract

In HEp-2 cells infected with herpes simplex virus the rate of protein synthesis at first decline, is stimulated between 4 and 8 hours after infection, and progressively and irreversibly declines from 9 to 16 hours later. The increase and decrease in rates coincide with corresponding changes in the amounts of cytoplasmic polysomes and amounts of labeled amino acids in nascent peptides bound to polysomes. The data indicate that (i) early and late inhibition and intervening stimulation of protein synthesis are due to the corresponding breakdown and formation of polysomes, and (ii) the bulk of viral proteins is probably made on cytoplasmic polysomes.

References

Jan 15, 1963·Proceedings of the National Academy of Sciences of the United States of America·J R WARNERA RICH
Oct 1, 1959·The Journal of Experimental Medicine·C MORGANE P JONES
May 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·S PenmanJ E Darnell

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Citations

Oct 30, 1999·European Journal of Immunology·M SalioA Lanzavecchia
Mar 1, 1988·Virus Genes·D R Yager, S L Bachenheimer
Jan 1, 1969·Archiv für die gesamte Virusforschung·F Rapp, M J Guentzel
Oct 1, 1967·Virology·U OlshevskyY Becker
Jul 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Brunella TaddeoBernard Roizman
Dec 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·L F Velicer, H S Ginsberg
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·Y Nishioka, S Silverstein
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M F ShihB Roizman
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A D Kwong, N Frenkel
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D P HajjarB D Summers
Feb 23, 2000·Journal of Virology·T M Soliman, S J Silverstein
May 1, 1990·American Journal of Respiratory Cell and Molecular Biology·R J KanerN A Kefalides
Nov 1, 2016·Nature Structural & Molecular Biology·Ranjan BatraGene W Yeo

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