Polysomnography-derived sleep parameters as a determinant of nocturnal blood pressure profile in patients with obstructive sleep apnea.

The Journal of Clinical Hypertension
Mitsuo KuwabaraKazuomi Kario

Abstract

Obstructive sleep apnea causes blood pressure (BP) surges during sleep, which may lead to increased sleep-onset cardiovascular events. The authors recently developed an oxygen-triggered nocturnal BP monitoring system that initiates BP measurements when oxygen desaturation (SpO2 ) falls below a variable threshold. The association between nocturnal BP parameters obtained by nocturnal BP monitoring and simultaneously examined polysomnography-derived sleep parameters in 116 patients with obstructive sleep apnea (mean age 57.9 years, 85.3% men) was studied. In multivariable analysis with independent factors of age, body mass index, sex, and polysomnography-derived measures (apnea-hypopnea index, apnea index, arousal index, lowest SpO2 , and SpO2  < 90%), apnea-hypopnea index (β = .26, P = .02) and lowest SpO2 (β = -.34, P < .001) were independent determinants of hypoxia-peak systolic BP (SBP), defined as the maximum SBP value measured by nocturnal BP monitoring. Similarly, apnea-hypopnea index (β = .21, P = .04) and lowest SpO2 (β = -.49, P < .001) were independent determinants of nocturnal SBP surge, defined as the difference between the hypoxia-peak SBP and the average of the SBP values within 30 minutes before and after the hypox...Continue Reading

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Citations

May 31, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
May 2, 2018·Hypertension·Kazuomi Kario
Jan 31, 2020·Frontiers in Aging Neuroscience·Jadwiga Attier-ZmudkaOlivier Balédent
Apr 14, 2020·Medical & Biological Engineering & Computing·Ayako KokuboKazuomi Kario
Feb 17, 2021·The Journal of Clinical Hypertension·Takeshi FujiwaraKazuomi Kario
Jul 28, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Frauke PicardRolf Michael Klein
Dec 23, 2021·The Journal of Clinical Hypertension·Ayako KokuboKazuomi Kario
Jan 1, 2022·Journal of the American Heart Association·Rong RenXiangdong Tang

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