Polysomnography during withdrawal with clomethiazole or placebo in alcohol dependent patients--a double-blind and randomized study

Pharmacopsychiatry
Horst GannDieter Riemann

Abstract

The present study was designed to assess if the routine application of clomethiazole to ameliorate withdrawal symptoms in chronic alcohol dependent patients perpetuates sleep disturbances. Twenty inpatients with alcohol dependence according to DSM-IV criteria received clomethiazole or placebo in a double-blind, randomized design upon admission. 11 patients were randomized to the clomethiazole group and 9 patients to the placebo group. During the first 5 days of treatment the patients received either clomethiazole (1st day: 3 x 384 mg, 2nd day: 4 x 384 mg, 3rd day: 3 x 384 mg, 4th day: 2 x 384 mg and 5th day: 1 x 384 mg) or placebo capsules at constant intervals. The patients spent two consecutive nights in the sleep laboratory at each of three assessment times: the first time at the beginning of abstinence (night 1 and 2, T0), the second time 6 days later (i. e. after 5 days of treatment and one day of discontinuation of clomethiazole or placebo: nights 6 and 7, T1) and the third time after 13 days (nights 13 and 14, T2). The first night at each of the three assessment times was an adaptation night. During the first two weeks of abstinence, the analysis of variance demonstrated a significant variation of Rapid Eye Movement (REM...Continue Reading

Citations

Oct 21, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Bethany K BrackenScott E Lukas
Jul 1, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Bhanu Prakash KollaTerry Schneekloth
Feb 6, 2010·Drugs·Thomas Roth, UNKNOWN Workshop Participants
May 3, 2005·European Archives of Psychiatry and Clinical Neuroscience·Horst GannDieter Riemann
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Bernd FeigeDieter Riemann
Apr 5, 2008·Brain Research·Sanjib MukherjeeSteven M Simasko
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Subhajit ChakravortyKirk J Brower
Jun 17, 2011·The Cochrane Database of Systematic Reviews·Laura AmatoMarina Davoli
Sep 25, 2017·Journal of Sleep Research·Mary Beth MillerChristina S McCrae
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Silvia MinozziMarina Davoli
Jun 25, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Ian M Colrain

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