PMID: 7515657Mar 1, 1994Paper

Polysomy of chromosome 12 in 60 patients with non-Hodgkin's lymphoma assessed by fluorescence in situ hybridization: differences between follicular and diffuse large cell lymphoma

Genes, Chromosomes & Cancer
A YounesM Andreeff

Abstract

Sixty consecutive evaluable specimens from patients with non-Hodgkin's lymphoma (NHL) were studied for the incidence of polysomy of chromosome 12 by fluorescence in situ hybridization (FISH) with probes for the repetitive DNA sequence in the centromeric region of chromosome 12. Thirty-six samples were from follicular lymphomas (FLs), and twenty-four were from diffuse large cell lymphomas (DLCLs). Fifty-two specimens (86%) were obtained by fine-needle aspiration of a diseased node, seven (11.6%) were from involved bone marrows, and one specimen was from a pleural effusion. Twelve of the thirty-six (33%) cases with FL had trisomy 12 in 3-41% of the cells (median, 10%) (normal controls had three signals in 1.4 +/- 0.7% of cells). Trisomy 12 was found in 62% of the patients who had had FL for more than 5 years. Nine of the twenty-four cases (37%) with DLCL had more than two copies of chromosome 12 in 4-92% of the cells (median, 78%), and all nine cases were of B-cell phenotype. Unlike FL cells, some DLCL cells had 4-6 copies of chromosome 12. In previously untreated patients, 54% of DLCLs and 26% of FLs had subpopulations of cells containing more than two copies of chromosome 12 (P = 0.04). Only 2/7 cases of DLCL with polysomy 12 h...Continue Reading

References

Jun 1, 1992·Genes, Chromosomes & Cancer·I WlodarskaJ J Cassiman
May 1, 1992·Cancer Genetics and Cytogenetics·Y HirabayashiA Tonomura
Jun 1, 1992·Cancer Genetics and Cytogenetics·P RobertsG Batcup
Jul 1, 1992·Cancer Genetics and Cytogenetics·D W HammondM H Goyns
Dec 1, 1988·Cancer Genetics and Cytogenetics·C MecucciH Van den Berghe
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ W Gray
Jan 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J E RomagueraF Cabanillas

❮ Previous
Next ❯

Citations

Jan 20, 2007·Journal of Cancer Research and Clinical Oncology·Hege Vangstein AamotSverre Heim
Sep 10, 2003·Seminars in Cancer Biology·Andreas a ViardotMartin Bentz
Oct 19, 2004·The American Journal of Surgical Pathology·Amy ChadburnDaniel M Knowles
Aug 28, 1998·Leukemia & Lymphoma·T Knutsen
Dec 24, 2005·Pathology·Lynda J Campbell
Mar 1, 1996·Cancer Control : Journal of the Moffitt Cancer Center·S Alkan, D S Karcher
Dec 22, 2020·Frontiers in Oncology·Luciano CascioneFrancesco Bertoni
Mar 11, 2021·Cell Reports·Maria Virginia Ruiz CuevasJonathan W Yewdell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.