Polystyrene microsphere and 5-fluorouracil release from custom-designed wound dressing films

Progress in Biomaterials
Maryam Mobed-MiremadiMichel Goedert

Abstract

Custom-designed wound dressing films of chitosan and alginate have been prepared by a casting/solvent evaporation method for hydrophobic therapeutic agent encapsulation. In this parametric study, the propylene glycol (PG) and calcium chloride (CaCl2) concentrations were varied for chitosan and alginate films, respectively. Mechanical and chemical inter-related responses under observations included thickness (th), elasticity (E), tensile strength (TS), sorption ability (S%) and kinetics of in-vitro drug release, specifically in terms of membrane time to burst (tB) and duration of release (tR). As shown by results of a one tailed t-test significance testing at the 95% confidence interval (α = 0.05), alginate films were significantly more elastic (p = 0.003), thinner (p = 0.004) and more susceptible to osmotic burst (p = 0.011) and characterized by a longer duration of release (p = 0.03). Meanwhile chitosan films exhibited superior moisture permeability (p = 0.006) and sorption characteristics (p = 0.001), indicative of higher hydrophilicity. There were no significant differences in tensile strength (p = 0.324) for alginate and chitosan-based formulations. Preliminary testing was conducted using 0.71 μm in diameter microspheres fo...Continue Reading

References

Feb 13, 2001·International Journal of Pharmaceutics·H DurejaS Gupta
Sep 6, 2001·Journal of Pharmaceutical Sciences·L WangL Y Lim
Aug 21, 2003·Biochemical and Biophysical Research Communications·Yu-Bao WangYu-Zhen Wang
Feb 21, 2006·International Journal of Pharmaceutics·Sakchai Wittaya-areekul, Chureerat Prahsarn
Jan 27, 2010·Journal of Materials Science. Materials in Medicine·Xin MengFan Li
Sep 16, 2010·AAPS PharmSciTech·Shiow-Fern NgGillian M Eccleston
Dec 12, 2012·Carbohydrate Polymers·Azadehsadat Hashemi DoulabiNasrin Samadi

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Citations

Dec 1, 2014·Progress in Biomaterials·Robin AugustineSabu Thomas
Apr 2, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Sabra DjomehriSindy Liao-Chan
Nov 11, 2020·Journal of Medical Engineering & Technology·Isaac O Igba, Solomon C Nwigbo
Oct 5, 2021·Expert Opinion on Drug Delivery·Munira MominAbdelwahab Omri

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BETA
light scattering
atomic force microscopy
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scanning electron microscopy

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