Abstract
Polysulfides are a typical type of bound sulfur, which is physiologically stable form of sulfur species, derived from the hydrogen sulfide (H2S) that is generated endogenously in cells. We previously reported that bound sulfur protects neuronal cells from oxidative injury. In the present study, we demonstrated that polysulfides inhibited cell growth and promoted neurite outgrowth in mouse neuroblastoma Neuro2A (N2A) cells. However, Na2S showed no effect on neurite outgrowth in N2A cells. Furthermore, 2-APB and SKF96365, which are typical transient receptor potential (TRP) channel inhibitors, suppressed the neurite outgrowth induced by Na2S4. These new findings suggest that bound sulfur could induce neurite outgrowth and cell differentiation of N2A cells by accelerating calcium influx.
References
Jan 1, 1986·Annual Review of Nutrition·M H Stipanuk
Dec 1, 1994·Biological & Pharmaceutical Bulletin·Y OgasawaraS Tanabe
Aug 28, 1997·Biochemical and Biophysical Research Communications·R HosokiH Kimura
Aug 11, 1998·Neuron·M J Berridge
Jun 5, 2001·Nature Reviews. Neuroscience·D E ClaphamC Strübing
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yasuo NagaiHideo Kimura
May 25, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuka Kimura, Hideo Kimura
Mar 1, 2005·Oncogene·Maria Elephteria EvangelopoulosAlex Krüttgen
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Biplab Dasgupta, Jeffrey Milbrandt
Feb 5, 2008·Pediatric Clinics of North America·Julie R ParkHuib Caron
Aug 30, 2008·Antioxidants & Redox Signaling·Mari IshigamiHideo Kimura
Sep 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julie FurneMichael D Levitt
Nov 22, 2008·Pflügers Archiv : European journal of physiology·Yilin TaiYizheng Wang
Jun 9, 2009·Cellular and Molecular Life Sciences : CMLS·Danielle E Read, Adrienne M Gorman
Jul 4, 2009·Free Radical Biology & Medicine·Fei ZhaoDonna D Zhang
Sep 19, 2009·Journal of Biochemistry·Kunio KosakaTakuji Shirasawa
Oct 18, 2011·Experimental Cell Research·Mark A Marzinke, Margaret Clagett-Dame
Jan 24, 2013·Nature Communications·Norihiro ShibuyaHideo Kimura
Feb 16, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuka KimuraHideo Kimura
Sep 24, 2013·FEBS Letters·Shin KoikeKazuyuki Ishii
Citations
Apr 4, 2016·Neuroscience·J KubickovaO Krizanova
Apr 4, 2017·Redox Biology·Shin KoikeYuki Ogasawara
May 29, 2020·Antioxidants & Redox Signaling·Tsuyoshi TakataYasuo Watanabe
Apr 25, 2020·Biomolecules·Noriyuki Nagahara, Maria Wróbel
May 18, 2020·Neurotoxicity Research·Wanli GaoDing Wang
Apr 8, 2016·American Journal of Physiology. Cell Physiology·Amira Moustafa, Yoshiaki Habara
Nov 21, 2017·British Journal of Pharmacology·Noriyuki Nagahara
Nov 6, 2018·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Norihiro Shibuya
Jun 3, 2020·Biomolecules·Noriyuki Nagahara
Dec 30, 2020·Antioxidants & Redox Signaling·Peter RoseYi-Zhun Zhu
Dec 7, 2020·Redox Biology·Hai-Jian SunJin-Song Bian
Oct 19, 2017·Redox Biology·Mayumi IkedaToru Maruyama