Polysynaptic activation of the dentate gyrus of the hippocampal formation: an olfactory input via the lateral entorhinal cortex

Experimental Brain Research
R C Wilson, O Steward


The possibility that olfactory input is transmitted to specific subregions of the hippocampal formation via the entorhinal cortex was investigated electrophysiologically by analyzing the laminar profiles of potentials evoked in the hippocampal formation by stimulation of the lateral olfactory tract (LOT). LOT stimulation resulted in long latency (14--20 ms) evoked responses in the dentate gyrus of the hippocampal formation ipsilateral to the stimulation. The variable long latency of these responses and their inability to follow stimulus rates of 40/s suggested that these potentials reflected polysynaptic activation. Analysis of the laminar profiles of the evoked potentials indicated that the responses originated from a synaptic field localized in the outer portion of the stratum moleculare of the dentate gyrus, a terminal distribution which overlaps that of the lateral entorhinal cortical (LEC) projection to the dentate gyrus. Lesions of the LEC eliminated the long latency responses in the dentate gyrus evoked by LOT stimulation. In addition, a conditioning pulse delivered either to the LOT or to the LEC produced paired pulse potentiation of the response elicited by subsequent stimulation of the other structure. No evidence was...Continue Reading


Feb 27, 2008·Annals of Biomedical Engineering·Angelika DimokaTheodore W Berger
Jan 20, 1980·Brain Research·A M HabetsW J Mollevanger
May 7, 2002·Learning & Memory·Anne Marie Mouly, Rémi Gervais
May 1, 1997·The European Journal of Neuroscience·F A ChaillanB Soumireu-Mourat
Sep 24, 2010·Journal of Neurophysiology·Donald A Wilson, Xiaodan Yan
Jan 1, 1984·CRC Critical Reviews in Biochemistry·T K Mukkur
Jul 7, 1984·Journal of Theoretical Biology·C BruniA Germani
Feb 14, 2008·IEEE Transactions on Bio-medical Engineering·Angelika DimokaTheodore W Berger
Jun 1, 1987·European Journal of Biochemistry·S Citi, J Kendrick-Jones
Jul 26, 2000·Anesthesiology·K M TannerL S Leung
Jun 21, 2018·Frontiers in Behavioral Neuroscience·Mikhail A LebedevAlexei Ossadtchi
Apr 12, 2000·Journal of Neurophysiology·G Biella, M de Curtis
Dec 10, 2017·Brain Structure & Function·Andre L V Lockmann, Adriano B L Tort
Aug 24, 2017·The European Journal of Neuroscience·André L V LockmannAdriano B L Tort
Sep 3, 2002·Journal of Neurophysiology·Gerardo BiellaMarco de Curtis
Apr 26, 2018·Frontiers in Systems Neuroscience·Mikhail A Lebedev, Alexei Ossadtchi
Aug 1, 1985·The Journal of Comparative Neurology·T Van Groen, F H Lopes da Silva
May 20, 1981·The Journal of Comparative Neurology·K C KoselJ R West
Feb 8, 1990·The Journal of Comparative Neurology·W K SchwerdtfegerP Germroth

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