Polyunsaturated fatty acids and peripheral artery disease.

Vascular Medicine
S Marlene GrenonMichael S Conte

Abstract

There is substantial evidence that polyunsaturated fatty acids (PUFAs) such as n-3 and n-6 fatty acids (FAs) play an important role in prevention of atherosclerosis. In vitro and in vivo studies focusing on the interactions between monocytes and endothelial cells have explored the molecular effects of FAs on these interactions. Epidemiological surveys, followed by large, randomized, control trials have demonstrated a reduction in major cardiovascular events with supplementation of n-3 FAs in secondary prevention settings. The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review.

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Citations

Oct 12, 2012·Clinical Oral Investigations·A KenscheC Hannig
May 11, 2012·The Journal of Surgical Research·S Marlene GrenonMillie Hughes-Fulford
Feb 5, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Miguel Ruiz-Canela, Miguel A Martínez-González
Dec 24, 2014·Journal of Vascular Surgery·Emily V NosovaS Marlene Grenon
Jan 23, 2014·Circulation. Cardiovascular Genetics·Joseph V MoxonJonathan Golledge
Jun 21, 2020·Journal of Clinical Medicine·Sandi M AzabPhilip Britz-McKibbin
Jan 31, 2021·European Journal of Clinical Nutrition·Linda TramKim Overvad

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Methods Mentioned

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amputation
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Clinical Trials Mentioned

NCT01310270

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