Polyunsaturated fatty acids supplementation impairs anti-oxidant high-density lipoprotein function in heart failure

European Journal of Clinical Investigation
Raphael WurmKlaus Distelmaier

Abstract

The underlying reasons for the highly inconsistent clinical outcome data for omega-3-polyunsaturated fatty acids (n3-PUFAs) supplementation in patients with cardiac disease have not been understood yet. The aim of this prospective, randomized, double-blind, placebo controlled study was to determine the effects of oral treatment with n3-PUFAs on the anti-oxidant capacity of HDL in heart failure (HF) patients. A total of 40 patients with advanced HF of nonischaemic origin, defined by NT-proBNP levels of >2000 pg/mL, NYHA class III or IV and a LVEF <35% who were on stable optimized medical therapy for ≥3 months, were consecutively enrolled into this prospective, double-blind, placebo-controlled trial and randomized in a 1:1:1 fashion to receive 1 g/day or 4 g/day of n3-PUFA, or placebo, respectively, for 12 weeks. After 12 weeks of treatment, the anti-oxidant function of HDL, measured by the HDL inflammatory index, was found significantly impaired in the treatment group in a dose-dependent fashion with 0.67 [IQR 0.49-1.04] for placebo vs 0.71 [IQR 0.55-1.01] for 1 g/day n3-PUFA vs 0.98 [IQR 0.73-1.16] for 4 g/day n3-PUFA (P for trend = 0.018). We provide evidence for an adverse effect of n3-PUFA supplementation on anti-oxidant fun...Continue Reading

References

Sep 9, 2008·International Journal of Cardiology·Guy D EslickAlan Bensoussan
Sep 4, 2009·The Journal of Biological Chemistry·Arundhati UndurtiStanley L Hazen
Jul 20, 2010·Lancet·Palaniappan SaravananPhilip C Calder
Jan 14, 2011·The New England Journal of Medicine·Amit V KheraDaniel J Rader
Sep 13, 2012·JAMA : the Journal of the American Medical Association·Evangelos C RizosMoses S Elisaf
Nov 26, 2014·Nature Reviews. Cardiology·Darlington O Okonko, Ajay M Shah
May 21, 2015·European Journal of Clinical Investigation·Klaus DistelmaierGeorg Goliasch
Aug 28, 2016·European Heart Journal·Alberico L CatapanoUNKNOWN ESC Scientific Document Group
Dec 23, 2016·Journal of the American Heart Association·Lore SchrutkaLorenz Koller

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.