Polyurethane scaffold with in situ swelling capacity for nucleus pulposus replacement

Biomaterials
Zhen LiS Grad

Abstract

Nucleus pulposus (NP) replacement offers a minimally invasive alternative to spinal fusion or total disc replacement for the treatment of intervertebral disc (IVD) degeneration. This study aimed to develop a cytocompatible NP replacement material, which is feasible for non-invasive delivery and tunable design, and allows immediate mechanical restoration of the IVD. A bi-phasic polyurethane scaffold was fabricated consisting of a core material with rapid swelling property and a flexible electrospun envelope. The scaffold was assessed in a bovine whole IVD organ culture model under dynamic load for 14 days. Nucleotomy was achieved by incision through the endplate without damaging the annulus fibrosus. After implantation of the scaffold and in situ swelling, the dynamic compressive stiffness and disc height were restored immediately. The scaffold also showed favorable cytocompatibility for native disc cells. Implantation of the scaffold in a partially nucleotomized IVD down-regulated catabolic gene expression, increased proteoglycan and type II collagen intensity and decreased type I collagen intensity in remaining NP tissue, indicating potential to retard degeneration and preserve the IVD cell phenotype. The scaffold can be deliv...Continue Reading

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Citations

Jun 25, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zhen LiSibylle Grad
Jan 11, 2018·Journal of Tissue Engineering and Regenerative Medicine·Gernot LangZhen Li
Nov 17, 2019·International Journal of Molecular Sciences·Reihane ZiadlouSibylle Grad
Oct 5, 2020·Journal of Anatomy·Bao HuangFengdong Zhao
Jul 19, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marianna PeroglioMauro Alini
Jun 27, 2020·Frontiers in Bioengineering and Biotechnology·Zhen LiGernot Lang
Jul 28, 2020·Frontiers in Bioengineering and Biotechnology·Guoke TangXiaojian Ye
Dec 7, 2018·International Orthopaedics·Zorica BuserJeffrey C Wang
Nov 5, 2020·Tissue Engineering and Regenerative Medicine·Pinghui ZhouYingji Mao
Jan 16, 2021·International Journal of Molecular Sciences·Laura BaumgartnerJérôme Noailly
Feb 22, 2017··Mohd Al Amin Muhamad NorKhairul Anuar Mat Amin

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