Polyvinyl alcohol gel prevents adhesion re-formation after adhesiolysis in a rabbit model

The Journal of Surgical Research
Reinhold Andreas LangMartin Hartwig Kirschner

Abstract

Chronic pain, infertility, and bowel obstructions are possible consequences of abdominal adhesions, which can highly affect the patient's quality of life. Patients in whom adhesiolysis has been performed are at high risk for recurrence of adhesions. For that reason, the present study focused on the re-formation of adhesions after adhesiolysis and on the possibility of avoiding it by using the adhesion barrier polyvinyl alcohol (PVA)-gel. A randomized controlled study was conducted to prove the effectiveness of PVA-gel in reducing postoperative adhesion re-formation after relaparotomy. Moreover, ultrasound was evaluated as a noninvasive technique to determine abdominal adhesion in a rabbit model. All animals underwent an initial laparotomy to cause adhesions and subsequent adhesiolysis in the relaparotomy. PVA-gel was placed onto a side wall defect in 12 animals. Another 12 rabbits served as a control group without PVA-gel being used. Ultrasound before final laparotomy was performed to predict the prevalence of adhesions. Macroscopic evaluation of adhesion formation and planimetry were used to determine the amount of adhesion. PVA-gel was found to reduce significantly the amount of adhesion formation after relaparotomy (P = 0.00...Continue Reading

References

Jul 1, 1992·Journal of Clinical Ultrasound : JCU·I KodamaA K Sachdeva
Jan 1, 1991·Surgical Endoscopy·B SigelH A Zaren
Sep 1, 1989·The Australian and New Zealand Journal of Surgery·A L Sparnon, L Spitz
Sep 19, 1998·The Journal of Small Animal Practice·C A WackerJ Lang
Dec 9, 1998·Digestive Surgery·M SchäferM W Büchler
Sep 6, 2000·The British Journal of Surgery·G MillerP H Gordon
May 26, 2001·Langenbeck's Archives of Surgery·A TittelV Schumpelick
Jun 18, 2004·The Journal of the American Association of Gynecologic Laparoscopists·Ludovico Muzii
Jul 3, 2004·Current Opinion in Obstetrics & Gynecology·Dingeman J Swank, Hans Jeekel
Jan 27, 2005·American Journal of Obstetrics and Gynecology·Frank F TuJohn F Steege
May 8, 2007·Fertility and Sterility·Reinhold Andreas LangMartin Hartwig Kirschner
Jun 15, 2007·The Journal of Surgical Research·Kevin CooperKathleen E Rodgers
Jun 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoon YeoDaniel S Kohane

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