Polyvinyl alcohol nanofiber formulation of the designer antimicrobial peptide APO sterilizes Acinetobacter baumannii-infected skin wounds in mice

Amino Acids
Istvan SebeLaszlo Otvos

Abstract

Native and designer cationic antimicrobial peptides are increasingly acknowledged as host defense molecules rather than true antimicrobials. Due to their ability to activate the innate immune system, these structures are used to treat uninfected and bacterially-infected wounds, including those harboring Acinetobacter baumannii. Previously we documented that when administered intramuscularly or topically in liquid formulations, the proline-rich host defense peptide dimer A3-APO accelerates uninfected wound re-epithelization and eliminates systemic and local A. baumannii, methicillin-resistant Staphylococcus aureus and other pathogen load from infected lesions better than conventional antibiotics. In the current study we sought to produce and characterize a novel delivery system, suitable for immediate and convenient application in non-hospital environments. The APO monomer was incorporated into polyvinyl alcohol nanofibers and the complex was polymerized into a solid patch dressing. Mice were subjected to skin abrasion where the wounds were either left uninfected or were inoculated with a near lethal dose of multidrug resistant A. baumannii strain. Analyzed after 3 days, APO monomer-containing patches improved wound appearance s...Continue Reading

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Citations

Feb 6, 2017·Advances in Colloid and Interface Science·Randi Nordström, Martin Malmsten
Apr 24, 2018·Therapeutic Delivery·Ankit JaviaAmbikanandan Misra
Jul 25, 2019·Macromolecular Bioscience·Alexander DartPeter Kingshott
Sep 29, 2020·Frontiers in Cellular and Infection Microbiology·Yongqing LiuChen Wang
Apr 13, 2018·Frontiers in Pharmacology·Anja PfalzgraffGünther Weindl
Mar 30, 2016·Materials·Ji Wang, Wilfred Vermerris
Aug 6, 2019·Frontiers in Microbiology·Faye C MorrisAnton Y Peleg
Aug 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan Q XiongCarl N Kraus
Dec 5, 2020·Pharmaceutics·Caroline S A de LimaGustavo H C Varca
Aug 20, 2016·Acta Microbiologica Et Immunologica Hungarica·Laszlo Otvos
Mar 21, 2021·Drug Discovery Today·Maurício G C SousaOctávio L Franco
Jul 23, 2021·International Journal of Pharmaceutics·Sofia ValentiJordi Puiggalí

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