PMID: 9556760Apr 29, 1998Paper

Poly(vinyl alcohol) synthetic polymer foams as scaffolds for cell encapsulation

Journal of Biomaterials Science. Polymer Edition
R H LiT Hazlett

Abstract

Poly(vinyl alcohol) (PVA) foams were used as scaffolds in hollow fiber membrane-based cell encapsulation devices. The surrounding permselective membrane serves as an immunoisolation barrier while allowing metabolites and other small molecules to be freely transported. The internal matrix defines the microenvironment for the encapsulated cells. PC12 cell-containing devices represent one possible strategy for safe transplantation of dopamine-secreting cells for the treatment of dopamine-deficient diseases such as Parkinson's disease. PC12 cells--a dopamine-secreting cell line--were encapsulated with PVA foam as a matrix material in the lumen of these hollow fibers. In this work, we demonstrate the presence of the PVA matrix increased the catecholamine secretion efficiency of the cells as compared to devices containing a chitosan matrix. Devices were implanted in vivo into rodent striatum and device output of catecholamines was measured preimplant and post-explant. Evoked stores of dopamine remained constant (preimplant vs explant) for devices encapsulated with the foam matrix and increased with devices encapsulated with chitosan matrix. Cell proliferation within devices was inhibited in the presence of the foam matrix. Cell viabi...Continue Reading

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·R H Li
Dec 10, 1999·Tissue Engineering·R H LiD Rein
May 21, 2009·Journal of Biomaterials Science. Polymer Edition·Sang Ho ChoJin Ho Lee
Jun 5, 2007·Der Unfallchirurg·G HolleG Germann
Dec 6, 2001·The Journal of Pharmacy and Pharmacology·M J WhitakerK M Shakesheff
May 3, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bernard Laurent SchneiderPatrick Aebischer
Aug 12, 2005·Neurorehabilitation and Neural Repair·W-L Kuan, R A Barker
Sep 1, 2005·Journal of Biomaterials Science. Polymer Edition·Sang Ho ChoJin Ho Lee
Jul 10, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Neethu Mohan, Prabha D Nair
Oct 18, 2008·Journal of Materials Science. Materials in Medicine·Lynda V ThomasPrabha D Nair
Aug 7, 2003·Journal of Biomaterials Science. Polymer Edition·Anna Aihua LiPatricia L Chang

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