Poly(vinyl chloride)-coated sol-gels for studying the effects of nitric oxide release on bacterial adhesion

Biomacromolecules
Brian J Nablo, Mark H Schoenfisch

Abstract

Nitric oxide (NO) releasing sol-gel materials coated with poly(vinyl chloride) (PVC) films exhibit increased stability at ambient and physiological temperatures. The polymer overcoat, however, reduces the NO fluxes by 5-35% over the initial week of release. The variation in NO fluxes between unmodified and PVC-coated sol-gels is negligible after 7 days. The PVC polymeric layer provides controlled surface chemistry for systematic studies of the effects of NO release on bacterial adhesion. As an example, the adhesion of Pseudomonas aeruginosa and Proteus mirabilis at PVC-coated NO-releasing sol-gels is investigated. A direct NO dependence on the reduction of P. aeruginosa adhesion is observed for NO fluxes up to 20 pmol cm(-2) s(-1). Although decreased by 50% in the presence of NO release, P. mirabilis adhesion does not appear to correlate to the flux of NO release. PVC-coated NO-releasing sol-gels may prove useful for studying the effects of localized NO release on other biological and chemical systems.

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Citations

Aug 29, 2006·Chemical Society Reviews·Evan M Hetrick, Mark H Schoenfisch
Jun 27, 2006·The Analyst·Jae Ho Shin, Mark H Schoenfisch
Mar 1, 2012·Chemical Society Reviews·Daniel A Riccio, Mark H Schoenfisch
Mar 1, 2012·Chemical Society Reviews·Alexis W Carpenter, Mark H Schoenfisch
Jan 20, 2012·ACS Applied Materials & Interfaces·Daniel A RiccioMark H Schoenfisch
Nov 30, 2013·Biomaterials Science·Scott P Nichols, Mark H Schoenfisch
Jul 29, 2008·Biomaterials·Gregory W CharvilleMark H Schoenfisch
Jul 29, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lingzhou ZhaoZhifen Wu
May 7, 2008·Angewandte Chemie·Russell E Morris, Paul S Wheatley
Feb 18, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hongshuai LiBingyun Li
Jan 25, 2012·Advanced Functional Materials·Michele C JenGuillermo A Ameer
Feb 18, 2006·Biosensors & Bioelectronics·Mark H SchoenfischKevin P Dobmeier
Jun 28, 2005·Biomaterials·Brian J NabloMark H Schoenfisch
Sep 11, 2014·Journal of Biomedical Materials Research. Part a·Wesley L StormMark H Schoenfisch
May 7, 2014·Acta Biomaterialia·Wesley L StormMark H Schoenfisch
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Nhiem TranChristopher T Born
Jun 9, 2009·Biomaterials·Daniel A RiccioMark H Schoenfisch
Nov 11, 2017·Polymers·George FlemingRaechelle A D'Sa
Jan 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jihoon KimWon Jong Kim
May 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zahra SadrearhamiCyrille Boyer
Nov 4, 2008·The Journal of Physical Chemistry. B·John J KoehlerJenna L Rickus
Jan 10, 2017·ACS Applied Materials & Interfaces·Alec LutzkeMelissa M Reynolds
Mar 23, 2007·Journal of the American Chemical Society·Jae Ho ShinMark H Schoenfisch

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