Pomegranate (Punica granatum) peel is effective in a murine model of experimental Cryptosporidium parvum

Experimental Parasitology
Ebtisam M Al-Mathal, Afaf A Alsalem

Abstract

Cryptosporidiosis, a major health issue for neonatal calves, is caused by the parasite Cryptosporidium parvum, which is highly resistant to drug treatments. To date, many anti-parasitic drugs have been tested, but only a few have been shown to be partially effective in treating cryptosporidiosis. Previous studies have indicated that pomegranate (Punica granatum) possesses anti-plasmodium, anti-cestode, and anti-nematode activities. Therefore, the aim of this study was to evaluate the effect of P. granatum peel on suckling mice infected with experimental C. parvum. At 4days of age, 72 neonatal albino mice were randomly divided into five groups: G1: healthy controls, G2: infected/untreated controls, G3: uninfected/distilled water-treated, G4: uninfected/P. granatum peel-treated, and G5: infected/P. granatum peel-treated. Mice were experimentally-infected by oral administration of 1×10(3)C. parvum oocysts per animal. On day 7 post-inoculation (pi), treated mice received an aqueous suspension of P. granatum peel orally (3g/kg body weight). The presence of diarrhea, oocyst shedding, and weight gain/loss, and the histopathology of ileal sections were examined. Infected mice treated with the P. granatum peel suspension showed improvem...Continue Reading

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Citations

Sep 15, 2016·Parasite : Journal De La Société Française De Parasitologie·Klaus TeichmannFranz Hadacek
Jul 3, 2019·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·D AboelsouedF M Abu-Salem
Jul 3, 2021·Antibiotics·Asmaa M El-KadyHatem A Elshabrawy

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