Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans

Clinical Pharmacology and Therapeutics
Julie GrenierM P Ducharme

Abstract

Cyclosporine (INN, ciclosporin) is a cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp) substrate whose bioavailability increases when administered with grapefruit juice. It is unknown whether pomelo, a closely related citrus fruit, interacts with cyclosporine in humans. In addition, a case study reports that cranberry juice interacts with warfarin, a drug with a narrow therapeutic range. Cranberries have a high content of flavonoids, compounds with various metabolic effects, including interaction with P-gp in vitro. Although the effect of flavonoids is less evident in vivo, cranberry juice has become a very popular beverage, and it was deemed important to investigate whether it has an effect on the disposition of cyclosporine, another drug with a narrow therapeutic range. In an open-label, randomized, 3-way crossover study with a 14-day washout period between each dose, 12 healthy male volunteers received single oral 200-mg doses of cyclosporine according to the following regimens: 200 mg cyclosporine administered with 240 mL of pomelo juice, cranberry juice, or water under fasting conditions. Multiple whole blood samples were collected up to 36 hours after each dose. Concentrations were determined via a liquid chromatography-...Continue Reading

Citations

Dec 31, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ngoc NgoMary F Paine
Sep 23, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hana BártíkováBarbora Szotáková
Dec 22, 2009·Expert Opinion on Drug Safety·Deborah A Kennedy, Dugald Seely
Feb 3, 2007·Expert Opinion on Drug Metabolism & Toxicology·Mary F Paine, Nicholas H Oberlies
Jun 24, 2009·Expert Opinion on Drug Metabolism & Toxicology·Wenxia ZhangLee Yong Lim
Apr 25, 2008·Expert Opinion on Drug Metabolism & Toxicology·Dora Farkas, David J Greenblatt
Nov 12, 2010·Expert Opinion on Drug Metabolism & Toxicology·Clemence TariraiJosias H Hamman
Aug 21, 2013·BioMed Research International·F I Al-JenoobiMohd Raish
Feb 26, 2016·Drug Metabolism Reviews·Thomas VanhoveDirk R J Kuypers
Mar 12, 2008·Basic & Clinical Pharmacology & Toxicology·Bent H Hellum, Odd Georg Nilsen
Sep 2, 2006·Pharmacotherapy·Jonathan L AstonNancy L Shapiro
Apr 1, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yuzhen JiaJisen Xu
Sep 25, 2015·The Annals of Pharmacotherapy·Spencer H DurhamLea S Eiland
Jan 13, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Angelo A Izzo
Aug 21, 2007·Wiener medizinische Wochenschrift·Rainer Nowack
Oct 2, 2007·Journal of Thrombosis and Thrombolysis·Ann K Wittkowsky
Jun 3, 2008·British Journal of Pharmacology·M I Mohammed AbdulA J McLachlan
Jul 9, 2008·European Journal of Clinical Pharmacology·Wonku KangYoung-Ran Yoon
Nov 28, 2007·Nutrition Reviews·Diane L McKay, Jeffrey B Blumberg
Feb 27, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·David Q Pham, Antony Q Pham
Oct 16, 2009·European Journal of Clinical Pharmacology·Mutasim A Al-GhazawiSalah M AbuRuz
Jul 29, 2006·The Journal of Pharmacy and Pharmacology·Yoshihiro Uesawa, Kiminori Mohri
Mar 13, 2008·Nature Clinical Practice. Nephrology·Ruth M de Souza, Jonathon Olsburgh
Jan 26, 2012·Phytotherapy Research : PTR·Swathi VorugantiMadhusudan Rao Yamsani
Jan 11, 2012·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Stacy L HaberErin C Raney
Jul 12, 2013·Phytotherapy Research : PTR·Astrid Jordet Langhammer, Odd Georg Nilsen
Jun 19, 2014·Journal of Clinical Pharmacy and Therapeutics·I Peluso, M Palmery
Apr 29, 2018·Journal of Food and Drug Analysis·Meng ChenQuan Zhou
Jun 10, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Kannan Sridharan, Gowri Sivaramakrishnan
Nov 30, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Masashi NagataKazuhiko Arimori
May 12, 2017·EFSA Journal·UNKNOWN EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)Henk Van Loveren
May 16, 2009·Drugs·David R P Guay
Nov 20, 2014·Journal of Clinical Pharmacology·Wirin AnlamlertSirada Jones
Dec 31, 2020·Foods·Zvonimir PetricDanijela Bursać Kovačević
Apr 20, 2010·The American Journal of Medicine·Jennifer ZikriaJack Ansell
Jul 6, 2019·Critical Reviews in Oncology/hematology·Paul GougisRomain Coriat
Aug 12, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rainer Nowack, Wilhelm Schmitt
May 1, 2021·Critical Reviews in Oncology/hematology·Paul GougisChristian Funck-Brentano

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