Pomolic acid may overcome multidrug resistance mediated by overexpression of anti-apoptotic Bcl-2 proteins

Cancer Letters
Janaina FernandesCerli Rocha Gattass

Abstract

Multidrug resistance (MDR) is multifactorial and may be mediated by overexpression of anti-apoptotic proteins. This paper investigated whether pomolic acid (PA) was able to overcome resistance mediated by overexpression of Bcl-2 or BcL-xL. The results obtained showed that overexpression of these proteins partially inhibited the PA-induced apoptosis, loss of mitochondrial membrane potential and caspase -3 and -9 activation observed in HL-60/neo. Since Bcl-2 transfected cell lines were shown to be quite resistant to a series of chemotherapeutic agents, the data presented call attention to the possible clinical significance of PA as an anti-MDR drug.

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Citations

May 10, 2015·Biochemical and Biophysical Research Communications·Xian-wen ZhangJun Li
Oct 11, 2012·Natural Product Reports·Jorge A R SalvadorYongkui Jing
Aug 30, 2017·Oncology Reports·Lívia Paes Tavares Pacheco GuimarãesCerli Rocha Gattass
Sep 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji-Hyun ParkKwan-Kyu Park
Feb 26, 2015·Journal of Natural Products·Onat Kadioglu, Thomas Efferth
Jan 15, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lucas Bonfim MarquesElaine Maria Souza-Fagundes

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