PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure

Environment International
Karen HuenNina Holland

Abstract

PON1 is a multifunctional enzyme involved in oxidative stress and detoxification of some organophosphate (OP) pesticides. It has been associated with nervous system diseases like Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and autism. We previously found that PON1 susceptible genotypes were associated with lower IQ scores in children. Epigenetic marks, such as DNA methylation, can regulate gene expression. Yet, data on whether DNA methylation may influence the relationship between PON1 levels and neurobehavior are limited. In this study, we used Illumina 450K and EPIC BeadChip arrays to assess PON1 DNA methylation in blood specimens collected from children (n = 238) at birth (cord blood) and age 7 years and examined their relationship with cognitive outcomes. The Wechsler Intelligence Scale for Children was used to assess Full Scale IQ and four composite measures (Verbal Comprehension, Perceptual Reasoning, Working Memory, and Processing Speed Indexes) in 7-year-old children. We observed a consistent yet nonsignificant inverse relationship of methylation at several CpG sites close to the PON1 transcription start site with Full Scale IQ and other composite measures of cognition. We also found an inve...Continue Reading

Citations

Sep 18, 2020·Environmental Science and Pollution Research International·Diana Marcela Paredes-CéspedesYael Yvette Bernal-Hernández
Dec 7, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Susan K MurphyScott H Kollins
Dec 19, 2019·Environmental Science and Pollution Research International·Tahereh FarkhondehOmid Mehrpour
May 10, 2021·Clinical Epigenetics·Faten Taki, Inmaculada de Melo-Martin
Jun 28, 2019·Chemical Research in Toxicology·Diana M Paredes-CéspedesAurora E Rojas-García

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Related Papers

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
Reut GruberJulie Carrier
Journal of Autism and Developmental Disorders
Susan Dickerson Mayes, Susan L Calhoun
© 2022 Meta ULC. All rights reserved