Pooling is an insufficient strategy to avoid health care staff to patient transmission of SARS-CoV-2

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Jessica LüsebrinkOliver Schildgen

Abstract

In order to save the limiting resource of RNA extraction kits we have evaluated the efficacy of pre-extraction sample pooling for SARS-CoV-2 RT-PCR screenings in medical staff. Unfortunately, in contrast to other reports, this strategy results in a loss of sensitivity between 25 to 71% compared to single sample testing, thus making the strategy inappropriate for the current setting.

References

Apr 29, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Bernard La ScolaDidier Raoult
May 12, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Monika MaleckiAndreas F Wendel
May 15, 2020·Nature Medicine·Jie ZhouKwok Yung Yuen
May 18, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Adriana CalderaroCarlo Chezzi
Jun 13, 2020·The Lancet Infectious Diseases·Stefan LohseSigrun Smola

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Methods Mentioned

BETA
bronchoalveolar lavage
bronchoalveolar lavages
PCR

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