Poor chemotherapy-induced nausea and vomiting control in children receiving intermediate or high dose methotrexate

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Helen VolL Lee Dupuis

Abstract

Chemotherapy emetogenicity is the most important known determinant of chemotherapy-induced vomiting (CIV) in children. However, direct evidence regarding the emetogenic potential of chemotherapeutic agents in children is limited. This study describes the prevalence of complete control of acute and delayed phase chemotherapy-induced nausea and vomiting (CINV) in children receiving methotrexate. The prevalence of anticipatory CINV is described, and risk factors for CINV are explored. English-speaking children (4 to 18 years) receiving intermediate-dose (ID-MTX: >1 to <12 g/m(2)/dose) or high-dose methotrexate (HD-MTX: ≥12 g/m(2)/dose) participated in this prospective study. Emetic episodes, nausea severity, and antiemetic administration were documented for 24 h from the start of the methotrexate infusion (acute phase) and for up to a further 168 h (delayed phase). CINV prophylaxis was provided at the discretion of the treating physician. Anticipatory CINV was assessed in the 24 h preceding chemotherapy. Complete CINV control was defined as no emetic episodes and no nausea. Thirty children (mean age, 11.8 ± 4 years; ID-MTX, 20; HD-MTX, 10) completed the study. CINV prophylaxis included the following: ondansetron/granisetron plus d...Continue Reading

Associated Clinical Trials

References

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Oct 26, 2013·European Journal of Pharmacology·David Warr
Jun 19, 2014·Pediatric Blood & Cancer·Jason L FreedmanChris Feudtner

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Citations

Jun 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Priya PatelL Lee Dupuis
Jul 17, 2019·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Mary C Hooke, Lauri A Linder
Aug 28, 2019·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·E Anne LownFrederick M Hecht

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