Poor glycemic control induces hypertension in diabetes mellitus

Hypertension
Michael W Brands, T E Hopkins

Abstract

We conducted this study to test the hypothesis that hypertension is a primary consequence of poor glycemic control per se very early in insulin-dependent diabetes mellitus. Sprague-Dawley rats (n=15) were instrumented with artery and vein catheters, placed in metabolic cages, and sodium intake was clamped throughout the study. Mean arterial pressure was measured 24 h/d. After a precontrol period, streptozotocin (70 mg/kg IV) was administered, and 15 hours later a continuous intravenous infusion was begun at 4 U/rat per day. The insulin infusion was titrated on an individual rat basis to maintain good glycemic control, and after this 7-day control period, blood glucose, urinary sodium excretion, and mean arterial pressure were not different from precontrol values, averaging 8.8 +/- 0.6 mmol/L, 2.8 +/- 0.2 mmol/d, and 103 +/- 2 mm/Hg, respectively, for control days 5 through 7. Subsequently, a 4-day period of poor glycemic control was initiated by reducing the insulin infusion rate. Blood glucose, urinary sodium excretion, and mean arterial pressure began to increase on day 1; for diabetes days 3 and 4, they averaged 23.4 +/- 1.0 mmol/L, 3.6 +/- 0.1 mmol/d, and 110 +/- 2 mm Hg, respectively. All were significantly elevated. When ...Continue Reading

References

Nov 1, 1979·Metabolism: Clinical and Experimental·P SomaniA Rabinovitch
May 1, 1979·The American Journal of the Medical Sciences·A R ChristliebR H Underwood
Jan 1, 1992·Journal of Cardiovascular Pharmacology·M L Tuck, N Stern
Feb 1, 1991·American Journal of Hypertension·M W BrandsJ E Hall
Oct 1, 1989·Kidney International·S AndersonB M Brenner
May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T YamamotoW A Border
Feb 1, 1954·Journal of Applied Physiology·J H MILLER, M D BOGDONOFF

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Citations

Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Michael W Brands, Sharyn M Fitzgerald
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·G E Sonnenberg, T A Kotchen
Oct 19, 2007·American Journal of Nephrology·Daniela B VidottiMirian A Boim
Dec 4, 2010·The Journal of Veterinary Medical Science·Yukihito IshiiTakeshi Ohta
Jul 12, 2002·Clinical and Experimental Hypertension : CHE·Ja-Ryong KooNosratola D Vaziri
May 22, 2010·Diabetes Research and Clinical Practice·Rajan SainiAbdul Rashid Ismail
Dec 14, 2004·European Journal of Pharmacology·Santiago VillafañaEnrique Hong
May 23, 2006·Vascular Pharmacology·Vasudhevan T Chetty, Arya M Sharma
May 15, 2013·Journal of Diabetes Research·Ching-Hsia HungJhi-Joung Wang
Aug 20, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P RosenbaumS R G Ferreira
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S R FerreiraM T Zanella
Apr 26, 2008·Journal of Diabetes Science and Technology·S Srinivasa MurthyS Narasimha Murthy
Aug 1, 1996·Hypertension·T A Kotchen
Sep 18, 1998·Hypertension·M W Brands, S M Fitzgerald
Jun 30, 2006·Journal of the American Society of Nephrology : JASN·Tracy D BellMichael W Brands
Dec 8, 2005·American Journal of Physiology. Renal Physiology·Alaa S AwadMark D Okusa
Nov 28, 2013·The Journal of Pharmacology and Experimental Therapeutics·Luminita H PojogaRaouf A Khalil
Jul 9, 2020·International Journal of Hypertension·Mohammed Gebre DedefoTesfa Tekle Dibessa
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharyn M Fitzgerald, Michael W Brands
May 24, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·T Dylan OlverJ Kevin Shoemaker
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·M W BrandsA E Hailman
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·S M Fitzgerald, M W Brands
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·J A Miller

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