Poor in vivo efficacy of caspofungin, micafungin and amphotericin B against wild-type Candida krusei clinical isolates does not correlate with in vitro susceptibility results

Journal of Chemotherapy
Tamás KardosL Majoros

Abstract

We determined micafungin, caspofungin and amphotericin B (AMB) minimum inhibitory concentration (MICs) and killing rates in RPMI-1640 and in RPMI-1640 with 50% serum against three Candida krusei bloodstream isolates. MIC ranges in RPMI-1640 were 0.125-0.25, 0.25 and 0.125-0.5 mg/L, in RPMI-1640 with 50% serum, MICs were 64-128-, 8- and 4-16-fold higher, respectively. In RPMI-1640 micafungin and caspofungin at 1, 4, 16 and 32 mg/L as well as AMB at 2 mg/L were fungicidal against all isolates in ≤3.96, ≤4.42 and 14.96 h, respectively. In RPMI-1640 with 50% serum, caspofungin was fungicidal for all isolates only at 32 mg/L, micafungin and AMB were fungistatic. In neutropenic mice, 5 mg/kg caspofungin and 1 mg/kg AMB were ineffective against two of the three isolates. Thus, in vivo efficacy of echinocandins and AMB is weak or absent against C. krusei. Prescribers treating C. krusei infections with echinocandins should watch out for clinical resistance and therapeutic failure.

References

Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Russell E Lewis, Nathan P Wiederhold
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Emilia CantónAna Espinel-Ingroff
Oct 24, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L MajorosC Kiss
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Aug 4, 2010·Journal of Clinical Pharmacology·Elizabeth M MigoyaJohn A Wagner
Oct 1, 2010·American Journal of Hematology·Naoe GotoHisataka Moriwaki
Dec 24, 2010·Drugs·Sharon C-A ChenTania C Sorrell
Mar 1, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·M A PfallerUNKNOWN CLSI Subcommittee for Antifungal Testing
Apr 27, 2011·Antimicrobial Agents and Chemotherapy·Amy M FlatteryGeorge K Abruzzo
May 4, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Noriaki YamadaShinji Ogura
Sep 14, 2011·Antimicrobial Agents and Chemotherapy·O A CornelyA H Groll
Oct 1, 2011·European Journal of Drug Metabolism and Pharmacokinetics·N UndreE Baraldi
Jun 26, 2012·Diagnostic Microbiology and Infectious Disease·Richárd FöldiLászló Majoros
Oct 5, 2013·Journal of Chemotherapy·Anna PrigitanoAnna Maria Tortorano
Jan 8, 2014·Clinical Microbiology Reviews·Timothy FeltonWilliam W Hope
Aug 7, 2014·Intensive Care Medicine·Olivier LortholaryUNKNOWN French Mycosis Study Group
Nov 5, 2014·Journal of Chemotherapy·M BaptistaD Virella
May 13, 2015·Antimicrobial Agents and Chemotherapy·Vincent J LempersRoger J Brüggemann
Aug 25, 2015·Journal of Medical Microbiology·Marianna DománLászló Majoros
Jan 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel
Mar 25, 2017·Journal of Chemotherapy·Franco AversaAndrea Novelli

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Citations

May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Shang SangXianlong Zhang

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