Poor levels of agreement between serum and saliva testosterone measurement following exercise training in aging men

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
Lawrence D HayesFergal M Grace

Abstract

Testosterone (T) is a biologically important androgen that demonstrates a widely-known natural decline with advancing age. The use of salivary T (sal-T), as a determinant of systemic T, has shown promising results in recent years. However, the strength of the salivary-serum T relationship may be affected by measurement method and binding capacity with salivary proteins. The potential influence exercise may impact on this relationship is unstudied in aging men. Therefore, the aim of the present investigation was to examine the relationship of the delta change (Δ) in sal-T with Δserum T following six weeks exercise training. Fifteen sedentary (SED) males (aged 60.4 ± 5.0 years of age) and 20 lifelong exercising (LE) males (60.4 ± 4.7 years of age) were participated. Pearson's correlation coefficient revealed sal-T did not correlate with total testosterone (TT), sex hormone binding globulin (SHBG), bioactive T (bio-T), or free T (free-T) at week 0 or week 6. Δsal-T did not correlate with ΔTT, ΔSHBG, Δbio-T or Δfree-T (r = 0.271, p = 0.180; r = 0.197, p = 0.335; r = 0.258, p = 0.205; and r = 0.257, p = 0.205, respectively). In conclusion, poor levels of agreement existed between saliva and serum measurements of T in response to exe...Continue Reading

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Citations

Jun 2, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Lawrence D HayesFergal M Grace
Apr 23, 2016·Hormones and Behavior·Kathleen V Casto, David A Edwards
Sep 21, 2016·American Journal of Men's Health·Sergio Varela KellesarianGeorgios E Romanos
Mar 27, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Melissa de Carvalho Souza VieiraAdriana Coutinho de Azevedo Guimarães
Jul 14, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·A WaltherC Kirschbaum
Oct 19, 2017·Molecular Medicine Reports·Junfeng ZhangZhen Zhan

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