Poor maternal care and high maternal body mass index in pregnancy as a risk factor for schizophrenia in offspring

Acta Psychiatrica Scandinavica
M KawaiN Takei

Abstract

We investigated whether antenatal factors in mothers would increase the risk of schizophrenia in the offspring, and also examined any relationship between these factors and histories of obstetric complications (OCs). Using the Mother and Child Health Handbooks of 52 patients with schizophrenia and 284 healthy subjects, we evaluated the risk-increasing effects of the frequency of antenatal care visits and mothers' body mass index (BMI) at both early and late pregnancy. In logistic regression analysis, there was a significant association between the number of antenatal care visits and the risk of the disorder; an increase in a unit of visits corresponds to a reduction of the risk by 12%. We also found a 24% increase in the risk with a one-unit increase of BMI at the early pregnancy, and a 19% increase at the late pregnancy. These antenatal factors were found to contribute, in part, to an excess of OCs in individuals with schizophrenia. Poor maternal care during pregnancy and comparatively high maternal BMI especially at early pregnancy may cause a predisposition to schizophrenia in the offspring.

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Citations

Sep 17, 2015·Pediatric Research·Jelske W van der BurgOlaf Dammann
Oct 20, 2010·Progress in Neurobiology·Alan S Brown
Apr 29, 2015·Hormones and Behavior·Elinor L SullivanJeanette C Valleau
Jun 16, 2006·Acta Psychiatrica Scandinavica·H J SørensenS A Mednick
Mar 19, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R J Van LieshoutM H Boyle
Dec 23, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G M KhandakerP B Jones
Jul 8, 2015·Frontiers in Neuroscience·Heidi M RiveraElinor L Sullivan
Mar 7, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Ryan J Van LieshoutMichael H Boyle
Feb 23, 2020·Journal of Developmental Origins of Health and Disease·Danielle J Burgess, Karen M Moritz
Nov 30, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Lilin Tong, Brian T Kalish
Feb 23, 2020·Frontiers in Neuroendocrinology·Seva G KhambadkoneKellie L K Tamashiro
Aug 28, 2021·Nutrients·Dawid GawlińskiIrena Smaga

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