Poor Prognostic Implication of ASXL1 Mutations in Korean Patients With Chronic Myelomonocytic Leukemia

Annals of Laboratory Medicine
Hyun Young KimHee Jin Kim

Abstract

Molecular genetic abnormalities are observed in over 90% of chronic myelomonocytic leukemia (CMML) cases. Recently, several studies have demonstrated the negative prognostic impact of ASXL1 mutations in CMML patients. We evaluated the prognostic impact of ASXL1 mutations and compared five CMML prognostic models in Korean patients with CMML. We analyzed data from 36 of 57 patients diagnosed as having CMML from January 2000 to March 2016. ASXL1 mutation analysis was performed by direct sequencing, and the clinical and laboratory features of patients were compared according to ASXL1 mutation status. ASXL1 mutations were detected in 18 patients (50%). There were no significant differences between the clinical and laboratory characteristics of ASXL1-mutated (ASXL1⁺) CMML and ASXL1-nonmutated (ASXL1⁻) CMML patients (all P>0.05). During the median follow-up of 14 months (range, 0-111 months), the overall survival (OS) of ASXL1⁺ CMML patients was significantly inferior to that of ASXL1⁻ CMML patients with a median survival of 11 months and 19 months, respectively (log-rank P=0.049). An evaluation of OS according to the prognostic models demonstrated inferior survival in patients with a higher risk category according to the Mayo molecul...Continue Reading

References

Oct 1, 2010·British Journal of Haematology·Véronique Gelsi-BoyerDaniel Birnbaum
Nov 27, 2010·Haematologica·Esperanza SuchGuillermo F Sanz
May 22, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raphaël ItzyksonEric Solary
Feb 6, 2016·Blood Cancer Journal·M M Patnaik, A Tefferi
May 18, 2016·American Journal of Hematology·Mrinal M Patnaik, Ayalew Tefferi

❮ Previous
Next ❯

Citations

Feb 15, 2019·International Journal of Molecular Sciences·Peter ValentHans-Peter Horny

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

SPSS Statistics
MDAPS

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.