PMID: 6973756Feb 1, 1981Paper

Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia

Postgraduate Medical Journal
R T DorrD W Barry

Abstract

A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was tested with trimethoprim/sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) or the suppository dose absorbed for TMP and SMX were 3.0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.

References

Dec 29, 1977·The New England Journal of Medicine·W T HughesS L George
Mar 1, 1979·Antimicrobial Agents and Chemotherapy·W E GroseT L Loo
Sep 23, 1976·The New England Journal of Medicine·W K Lau, L S Young
Oct 1, 1975·Archives of Dermatology·P Nitidandhaprabhas, D Sittapairochana
May 1, 1968·British Journal of Pharmacology and Chemotherapy·S R Bushby, G H Hitchings
Nov 1, 1970·Annals of Internal Medicine·K A WesternM G Schultz

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Citations

May 1, 1997·The Journal of Pharmacy and Pharmacology·J SallaiG Regdon

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