Poor survival for osteosarcoma of the pelvis: a report from the Children's Oncology Group.

Clinical Orthopaedics and Related Research
Michael S IsakoffG Douglas Letson

Abstract

The pelvis is an infrequent site of osteosarcoma and treatment requires surgery plus systemic chemotherapy. Poor survival has been reported, but has not been confirmed previously by the Children's Oncology Group (COG). In addition, survival of patients with pelvic osteosarcomas has not been compared directly with that of patients with nonpelvic disease treated on the same clinical trials. First, we assessed the event-free (EFS) and overall survival (OS) of patients with pelvic osteosarcoma treated on COG clinical trials. We then asked whether patient survival compared with that of patients treated on the same clinical trials with nonpelvic disease. Finally, we asked whether patients with metastatic disease at initial diagnosis had worse survival. We retrospectively reviewed data from 1054 patients with osteosarcoma treated in four studies between 1993 and 2005. Twenty-six of the 1054 patients (2.5%) had a primary tumor of the pelvis. At diagnosis, nine patients had metastatic disease. The minimum followup was 2 months (mean, 34 months; range, 2-102 months). Two of the nine patients with metastatic disease at diagnosis and five of the 17 with localized disease were alive at last contact. Estimates of the 5-year EFS for localized...Continue Reading

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Citations

Apr 3, 2016·The Bone & Joint Journal·M C ParryR J Grimer
Nov 16, 2016·JAAPA : Official Journal of the American Academy of Physician Assistants·Chelsea HillerChristopher P Forest
Mar 17, 2017·Biochemical and Biophysical Research Communications·Tewodros MamoMichael J Yaszemski
Jan 23, 2015·Pediatric Blood & Cancer·Jason GloverUNKNOWN COG Osteosarcoma Biology Group
Sep 20, 2015·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·W K GuderA Streitbürger
Sep 29, 2015·Pediatric Radiology·Sireesha YedururiNajat C Daw
Jun 24, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Aya NiimiYukio Homma
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Apr 15, 2016·Arkhiv patologii·D V RogozhinG V Tereshchenko
Oct 9, 2021·The Journal of the American Academy of Orthopaedic Surgeons·John H AlexanderDavid M Joyce

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