PMID: 7523701Nov 1, 1994Paper

Poor transduction efficiency of human hematopoietic progenitor cells by a high-titer amphotropic retrovirus producer cell clone

Journal of Virology
L C XuS Karlsson

Abstract

The transduction efficiency of human bone marrow CD34+ cells with supernatants from the retrovirus producer cell clone PA317/LGSN 16 was only one-fifth of that with supernatants from GP+ envAm12/LGSN 15, even though both producers had similar infection titers on 3T3 cells. PA317/LGSN 16-conditioned medium inhibited the proliferation of the bone marrow CD34+ cells, and this inhibitory effect was partially blocked by anti-transforming growth factor beta antibodies. These studies suggest that cytokine secretion plays a role in the suppression of retrovirus transduction of human CD34+ cells.

References

May 8, 1992·Science·W F Anderson
Jun 11, 1992·Nature·A D Miller
Jan 1, 1990·Human Gene Therapy·A D Miller
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K AssoianM B Sporn

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Citations

Jul 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Z DongI J Fidler
Jan 5, 2006·Human Gene Therapy·Grant TrobridgeHans-Peter Kiem
Jan 1, 1997·Stem Cells·M HavengaH H van Es

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