Abstract
A 48-year-old woman diagnosed with acromegaly 21 years earlier presented at our hospital with a left adrenal tumor. Her medical history included breast cancer, thyroid cancer and an incompletely resected growth hormone (GH)-producing pituitary adenoma. Endocrinological and radiological examinations revealed subclinical adrenal Cushing's syndrome. She subsequently underwent left adrenalectomy, followed by glucocorticoid replacement therapy. Her GH and insulin-like growth factor-1 levels were insufficiently controlled, and pegvisomant was administered in addition to octreotide acetate. Following adrenalectomy, a giant hepatic hemangioma and papillary thyroid carcinoma in the residual right lobe developed, indicating the high risk of tumor development in patients with acromegaly.
References
Apr 1, 1992·Journal of Endocrinological Investigation·H WatanobeK Takebe
Oct 25, 1991·Cancer·E RonJ F Fraumeni
Jan 1, 1988·Acta Medica Scandinavica·B A BengtssonB Sjögren
Jul 30, 1999·Endocrine Journal·R NasushitaT Suda
Apr 3, 2001·European Journal of Clinical Investigation·M M WeberE Wolf
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·C A StratakisJ A Carney
Nov 15, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jo K PerryPeter E Lobie
Jan 19, 2008·Endocrine Journal·Makiko KurimotoKazue Takano
Sep 13, 2008·Journal of Endocrinological Investigation·C ScaroniF Mantero
Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·Ferdous M BarlaskarGary D Hammer
Aug 12, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Judith A Hobert, Charis Eng
Aug 18, 2009·Endocrine·Alessandro CiresiCarla Giordano
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Lívia L CorrêaMônica R Gadelha
Jul 3, 2010·Journal of Endocrinological Investigation·F CeccatoC Scaroni
Sep 3, 2011·European Journal of Clinical Investigation·Theodora PappaGeorge Piaditis
Sep 17, 2011·Internal Medicine·Atsushi OgoShinsuke Hiramatsu