Poorly cytotoxic terminally differentiated CD56neg CD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas

Blood Advances
Catherine S ForconiAnn M Moormann

Abstract

Natural killer (NK) cells are critical for restricting viral infections and mediating tumor immunosurveillance. Epstein-Barr virus (EBV) and Plasmodium falciparum malaria are known risk factors for endemic Burkitt lymphoma (eBL), the most common childhood cancer in equatorial Africa. To date, the composition and function of NK cells have not been evaluated in eBL etiology or pathogenesis. Therefore, using multiparameter flow cytometry and in vitro killing assays, we compared NK cells from healthy children and children diagnosed with eBL in Kenya. We defined 5 subsets based on CD56 and CD16 expression, including CD56negCD16pos We found that licensed and terminally differentiated perforin-expressing CD56negCD16pos NK cells accumulated in eBL children, particularly in those with high EBV loads (45.2%) compared with healthy children without (6.07%) or with (13.5%) malaria exposure (P = .0007 and .002, respectively). This progressive shift in NK cell proportions was concomitant with fewer CD56dimCD16pos cells. Despite high MIP-1β expression, CD56negCD16pos NK cells had diminished cytotoxicity, with lower expression of activation markers NKp46, NKp30, and CD160 and the absence of TNF-α. Of note, the accumulation of poorly cytotoxic C...Continue Reading

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Citations

Apr 12, 2019·Parasite Immunology·Ann M MoormannCatherine S Forconi
Oct 2, 2019·Journal of Clinical Medicine·Ana P Gonzalez-RodriguezSegundo Gonzalez
May 7, 2020·Frontiers in Cellular and Infection Microbiology·Catherine S ForconiAnn M Moormann
Jun 17, 2020·Cellular & Molecular Immunology·Stephen TukwasibweFrancesco Colucci
Mar 7, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maria Del Pilar QuintanaLars Hviid
Jan 8, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Ratna S WijayaGolo Ahlenstiel
May 1, 2021·Cancers·Cecilia Nakid-CorderoVincent Vieillard
May 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Anne-Sophie ChretienDaniel Olive
Aug 11, 2021·Viruses·Yessica Sánchez-Ponce, Ezequiel M Fuentes-Pananá

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