Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown origin: favorable subsets of patients with unknown-primary carcinoma?

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
R LenziJ L Abbruzzese

Abstract

The objectives of this study were to assess clinical outcomes and prognostic factors in unselected, consecutive patients with poorly differentiated carcinoma (PDC) or poorly differentiated adenocarcinoma (PDA). The 1,400 patients analyzed were referred to our unknown-primary tumor (UPT) clinic from January 1, 1987 through July 31, 1994. Clinical data from these patients were entered into a computerized data base for storage, retrieval, and analysis. Survival was measured from the time of diagnosis; survival distribution was estimated using the product-limit method. Multivariate survival analyses were performed using proportional hazards regression and by recursive partitioning. Nine hundred seventy-seven patients were diagnosed with unknown-primary carcinoma (UPC) and 337 of these patients had PDC or PDA. No clinical differences were identified among patients with PDC, PDA, or UPC patients with other carcinoma or adenocarcinoma subtypes. PDC patients enjoyed better survival than PDA patients. Poor cellular differentiation was not an important prognostic variable. Variables predictive of survival included lymph node metastases, sex, number of metastatic sites, histology (PDC v PDA), and age. Although chemotherapy did not appear ...Continue Reading

Citations

Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E BriasoulisN Pavlidis
Aug 31, 2004·Journal of Surgical Oncology·Mitchell I ChorostBimal C Ghosh
Nov 4, 2011·Nature Reviews. Clinical Oncology·Christophe MassardKarim Fizazi
Jun 29, 2001·Japanese Journal of Cancer Research : Gann·H SumiY Sasaki
Apr 28, 2004·Cancer·Gauri R VaradhacharyRenato Lenzi
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy D GilliganUNKNOWN American Society of Clinical Oncology
May 20, 2006·Der Urologe. Ausg. A·S Seeber, D Strumberg
Nov 8, 2006·British Journal of Cancer·K B PittmanUNKNOWN Adelaide Cancer Trials and Education Collaborative (ACTEC)
Dec 13, 2012·International Journal of Cancer. Journal International Du Cancer·Kari HemminkiAkseli Hemminki
Jun 7, 2019·The Journal of Veterinary Medical Science·Oscar Rodrigo Sierra MatizMirela Tinucci-Costa
Oct 11, 2011·Journal of Neurosurgery. Spine·Michele R AizenbergLaurence D Rhines
Sep 30, 2009·American Journal of Clinical Oncology·Hirofumi MukaiToru Watanabe
Nov 19, 2020·Clinical Journal of Gastroenterology·Ippei TanakaTomoki Matsuda
Jun 4, 2008·Archives of Pathology & Laboratory Medicine·Guy Disibio, Samuel W French
Jul 24, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A LevyK Fizazi
Nov 26, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K HemminkiJ Sundquist
Mar 21, 2006·La Revue de médecine interne·P SèveC Broussolle

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