Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat

The Journal of Veterinary Medical Science
Yuko ShimadaTakanori Harada

Abstract

A subcutaneous pale brown-colored mass was observed macroscopically in the ventral neck of a 16-week-old Wistar rat on day 18 of gestation. The mass was well demarcated from the adjacent tissues with partial invasion into connective tissues. Necrosis and hemorrhage were evident throughout the mass. The mass comprised a diffuse sheet and a nest-like structure of epithelial cells with prominent squamous metaplasia. The neoplastic cells tested immunopositive for keratin, vimentin, glial fibrillary acidic protein and p63. A portion of the neoplastic cells exhibited a similar immunoreaction of prominin-1 to the ductal and acinar cells in normal submandibular and parotid glands. Collectively, the tumor was diagnosed as a poorly differentiated carcinoma derived from epithelial/myoepithelial lineages in the submandibular and/or parotid glands.

References

Mar 1, 1976·Journal of Dental Research·A Englander, E Cataldo
Dec 24, 1998·Toxicologic Pathology·T ImaiF Sagami
May 10, 2011·Journal of Applied Oral Science : Revista FOB·Maria Carolina Vaz GoulartVanessa Soares Lara
Jul 2, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lalitha S Y NanduriRobert P Coppes
Nov 19, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shuichi Fujita, Tohru Ikeda
Jun 1, 2013·Journal of Toxicologic Pathology·Yinghua LiBoo-Hyon Kang
Jun 7, 2013·Annals of the Rheumatic Diseases·Hye-Soon LeeSang-Cheol Bae

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