Pop a pill or give myself a shot? Patient perspectives of disease-modifying anti-rheumatic drug choice for rheumatoid arthritis.

Joint, Bone, Spine : Revue Du Rhumatisme
Jasvinder SinghSusan M Goodman

Abstract

To assess how patients with rheumatoid arthritis (RA) decide whether to add oral disease-modifying anti-rheumatic drugs (DMARDs) versus injectable biologic DMARDs when methotrexate response is inadequate. Using nominal group technique (NGT), RA patients answered the question "What sort of things are important to you when you make a decision between adding pills versus injectable medications to treat rheumatoid arthritis when methotrexate fails to control RA disease activity?" Patients nominated, discussed, and voted for the responses. Forty-seven RA patients participated: Birmingham (n=6 NG; 21 patients) and New York City (n=4 NG; 26 patients). They were predominantly female (85%), 70% white, with a mean age of 64.5 years and 58% had>10-year RA duration. Present/past DMARDs included methotrexate only in 6%, other traditional DMARDs in 15%, glucocorticoids in combination with traditional DMARDs in 11%, and biologics and/or Jak-kinase inhibitors in 68% of participants. Voted domains in order were: (1) efficacy/effectiveness and the onset/mode of action (78/282 votes); (2) side effects/fear of side effects (84/282 votes); (3) cost including out of pocket, co-payments and patient responsibility (54/282 votes); (4) convenience/frequ...Continue Reading

References

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Dec 20, 2014·Patient Preference and Adherence·Hanneke E ZwikkerCornelia H van den Ende
Nov 8, 2015·Arthritis & Rheumatology·Jasvinder A SinghTimothy McAlindon
Dec 17, 2017·Annals of the Rheumatic Diseases·Liana FraenkelCarole Wiedmeyer
Feb 14, 2018·Arthritis Care & Research·Jennifer L BartonChristopher J Koenig
Mar 3, 2018·Seminars in Arthritis and Rheumatism·Parvaneh HeidariKimberley Crawford
Sep 18, 2018·Arthritis Care & Research·Lucas GrisantiNorman Gaylis
Oct 20, 2018·Preventing Chronic Disease·Christiana OshotseCheryl Lin
Jul 20, 2019·International Journal of Rheumatic Diseases·Parvaneh HeidariKimberley Crawford

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