Poplar bark lipids enhance mouse immunity by inducing T cell proliferation and differentiation.

The Journal of Veterinary Medical Science
Jinxiu TangXingxiao Zhang

Abstract

Research on the composition and application of immune enhancers in livestock and poultry breeding has been gaining interest in recent years. Poplar bark lipids (PBLs), which are extracted from poplar tree bark, are natural substances known to efficiently enhance the immune response. To understand the chemical makeup of PBLs and their underlying mechanism for enhancing the immune system, we extracted PBLs from poplar bark using petroleum ether and subjected these extracts to chemical analysis. To evaluate PBLs effect on the immune system mice were treated with different doses of PBL via gavage and sacrificed 4 weeks later. PBLs were shown to be rich in vitamin E, unsaturated fatty acids, and other immune-potentiating compounds. Treatment with PBLs increased the spleen index and stimulated spleen and thymus development. In addition, PBLs increased the number of CD3+CD4+ cells in the peripheral blood and the ratio of CD4+/CD8+ cells while decreasing the number of CD3+CD8+ cells. Moreover, PBLs significantly increased IL-4 and IFN-γ levels in mouse serum and TLR4 mRNA and protein expression in the spleen. Taken together these results demonstrate that PBLs exert their immune-potentiating effects by promoting spleen and thymus develo...Continue Reading

References

Sep 1, 1990·The Journal of Nutrition·S MoriguchiY Kishino
Dec 12, 1997·The American Journal of Clinical Nutrition·A T BorchersM E Gershwin
Jan 1, 1997·Journal of Viral Hepatitis·R G GishJ Y Lau
Jan 6, 2000·Experimental Gerontology·A WakikawaK Hirokawa
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 2, 2005·Nature Reviews. Immunology·Reina E Mebius, Georg Kraal
Mar 21, 2007·Parasite Immunology·A RosbottomD J L Williams
Jun 24, 2011·Journal of Virology·Xiao-Ling PanGuo-Dong Liang
Aug 3, 2011·Expert Review of Vaccines·Emanuele MontomoliAlfonso De Rosa
Dec 3, 2011·International Journal of Biological Macromolecules·Yong ChenShujuan Liang
Dec 21, 2011·Journal of Animal Physiology and Animal Nutrition·A K SinghM Ashutosh
May 17, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Zhao-guo Li
Oct 2, 2013·International Journal of Biological Macromolecules·Yu-xia MeiYun-xiang Liang
Oct 23, 2013·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Qing-Hui YangXiao-Ge Kou
Jan 15, 2014·International Journal of Biological Macromolecules·Ting ZhaoXiangyang Wu
Oct 5, 2016·Mediators of Inflammation·Chuntao SunQianqi Liu
Feb 6, 2017·Journal of Ethnopharmacology·Yuhua LiLi Liu
Jun 6, 2017·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Fanxin MengDi Wang
Nov 2, 2019·International Journal of Biological Macromolecules·Wenfang LiKedong Song

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
flow cytometry
reverse-transcription PCR

Software Mentioned

ImageJ
GraphPad Prism
FlowJo
Cell Quest

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