PMID: 8597561Dec 1, 1995Paper

Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
I KockumA Lernmark

Abstract

A negative association between insulin-dependent diabetes mellitus (IDDM) and HLA-DR, DQA1 or DQB1 was found in a large population-based investigation of childhood-onset patients (more than 420 patients) and controls (more than 340 controls) from Sweden. The relative risk was decreased for several haplotypes that were negatively associated with IDDM: DR15-DQA1*0102-DQB1*0602, DR7-DQA1*0201-DQB1*0303, DR14-DQA1*0101-DQB1*0503, DR11-DQA1*0501-DQB1*0301, DR13-DQA1*0103-DQB1*0603 and DR4-DQA1*0301-DQB1*0301. In a relative predispositional effect (RPE) analysis, however, only the DR15-DQA1*0102-DQB1*0602 haplotype was significantly decreased, which suggests that the major protective effect for IDDM is carried by this haplotype. This was supported by the observation that all genotypes which were negatively associated with IDDM, except DR7/13, included at least one allele from the DR15-DQA1*0102-DQB1*0602 haplotype. Relative predispositional effect (RPE) analysis of genotypes showed further that the DR15-DQA1*0102-DQB1*0602 haplotype was also negatively associated with IDDM when combined with any other haplotype, whether negatively or positively associated with IDDM. This supports previous suggestions that DR15-DQA1*0102-DQB1*0602 act...Continue Reading

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Citations

Jul 2, 2005·Diabetologia·H E LarssonUNKNOWN DiPiS Study Group
Oct 1, 1996·Diabetes Research and Clinical Practice·J S DormanM Trucco
Jun 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A CarlssonUNKNOWN Swedish Better Diabetes Diagnosis Study Group
Feb 10, 2010·International Journal of Diabetes in Developing Countries·Oindrila RahaV R Rao
Jan 6, 2009·Annals of the New York Academy of Sciences·Carani B SanjeeviUNKNOWN Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups
Dec 6, 2008·International Journal of Immunogenetics·K AkessonI Kockum
Jul 9, 2004·Journal of Autoimmunity·Ramachandra G NaikBart O Roep
Dec 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·I KockumA Lernmark
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L S ArnesonA J Sant
May 22, 2002·Annals of the New York Academy of Sciences·Mona Landin-Olsson
Nov 20, 1998·Acta Paediatrica. Supplement·G Dahlquist

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