PMID: 15331558Aug 28, 2004Paper

Population-based assessment of familial clustering of diabetic nephropathy in type 1 diabetes

Diabetes
Valma HarjutsaloJ Tuomilehto

Abstract

We determined the magnitude of familial aggregation in the development of diabetic nephropathy (DN) among a population-based cohort of Finnish type 1 diabetic patients. Probands with type 1 diabetes were identified from the nationwide register of all Finnish cases diagnosed during 1965-1979. By 1998, there were 537 families with at least two siblings with type 1 diabetes. These 537 probands and their 616 diabetic siblings were followed for a diagnosis of DN until the end of 2001. We identified 323 cases of DN in these families. If the proband had DN, 38% of the siblings also had DN, whereas out of the diabetic siblings of the probands without DN, only 17% had DN (P = 0.001). Diabetic siblings of the nephropathic probands had a 2.3 times (95% CI 1.4-2.7) higher risk of DN compared with siblings of probands free of DN. The presence of a severe form of DN in the proband increases the risk threefold for diabetic siblings. Sex, the DN of the proband, the age at the onset of diabetes, and parental type 2 diabetes were significant predictors of DN among diabetic siblings. Although the majority of sibpairs with type 1 diabetes are discordant for DN, its presence in one sibling doubles the risk for the other diabetic siblings.

References

Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·S Korth-SchutzM I New
Apr 1, 1992·Kidney International·K Borch-JohnsenH H Parving
Jan 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·S J ConnellT L Dornan
Dec 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·P G McNallyA C Burden
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
May 1, 1997·Journal of Diabetes and Its Complications·C E Kullberg, H J Arnqvist
Feb 25, 1999·Clinical Science·T A ChowdhuryS C Bain
Aug 28, 2001·Diabetes Care·B P TabaeiW H Herman
Sep 14, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·J D RippinS C Bain
Mar 5, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jill Hamilton, Denis Daneman
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Pascale H Lane
Jun 6, 2003·The New England Journal of Medicine·Bruce A PerkinsAndrzej S Krolewski
Jun 26, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·L ZhangP J Lefèbvre

❮ Previous
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Citations

Oct 31, 2007·Diabetologia·P IhalmoUNKNOWN FinnDiane Study Group
Jun 26, 2012·Journal of Cardiovascular Translational Research·Andrew D Paterson, Shelley B Bull
Dec 26, 2008·DNA and Cell Biology·Tarunveer Singh AhluwaliaMadhu Khullar
May 23, 2013·QJM : Monthly Journal of the Association of Physicians·C J HillD G Fogarty
Mar 12, 2009·Current Opinion in Nephrology and Hypertension·Erin R Rademacher, Alan R Sinaiko
Feb 9, 2012·Current Opinion in Nephrology and Hypertension·Merlin C ThomasKarl Tryggvason
Jun 9, 2007·Seminars in Dialysis·Scott G SatkoBarry I Freedman
Sep 10, 2011·BMJ : British Medical Journal·Valma HarjutsaloPer-Henrik Groop
Apr 2, 2011·American Journal of Nephrology·Robert P IgoUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Oct 3, 2012·PLoS Genetics·Niina SandholmAlexander P Maxwell
May 3, 2011·PloS One·Ilana BlechBenjamin Glaser
Sep 13, 2011·PloS One·Maija WessmanUNKNOWN FinnDiane Study Group
Jul 1, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Patrícia Paz Cabral de Almeida SalgadoAna Cristina Simões e Silva
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Adriana M HungUNKNOWN AASK Study Group
Dec 25, 2012·Yi chuan = Hereditas·Jun-Yan LiHao Lu
Mar 7, 2014·Diabetologia·Niina SandholmUNKNOWN FinnDiane Study Group
Nov 8, 2014·Expert Opinion on Emerging Drugs·Giorgio GentileGiuseppe Remuzzi
May 1, 2010·Annals of Medicine·Riitta SallinenUNKNOWN Finnish Diabetic Nephropathy Study Group
May 2, 2014·Advances in Chronic Kidney Disease·Valma Harjutsalo, Per-Henrik Groop
Jul 10, 2012·Journal of Diabetes and Its Complications·Tianwei GuHarvest F Gu
Jan 11, 2007·Kidney International·H H KarnibA G Gharavi
Dec 24, 2015·Journal of Diabetes Research·Gareth J McKayAlexander P Maxwell
Sep 14, 2007·Pediatric Diabetes·Lorenzo PasqualiSteven Ringquist
Jan 1, 2016·Diabetes·Massimo PortaUNKNOWN FinnDiane Study Group
Apr 12, 2005·Advances in Chronic Kidney Disease·Grzegorz PlachaAndrzej S Krolewski
Apr 1, 2015·Nature Reviews. Nephrology·Emma AhlqvistMark I McCarthy
Dec 17, 2008·American Journal of Human Genetics·Bing HeKarl Tryggvason
Sep 21, 2016·Journal of the American Society of Nephrology : JASN·Niina SandholmUNKNOWN SUMMIT Consortium
Jan 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R S ScheffelL H Canani
Jul 3, 2018·Diabetes, Obesity & Metabolism·Valma HarjutsaloUNKNOWN FinnDiane Study Group
Nov 15, 2018·Diabetes·Scott G FrodshamMarcus G Pezzolesi
Aug 14, 2010·Journal of the American Society of Nephrology : JASN·Matthew D Breyer

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