Population-based assessment of the outcomes in patients with postcolonoscopy colorectal cancers

Gut
Anand GovindarajanNancy N Baxter

Abstract

The potential for cancers to not be detected on colonoscopy is increasingly recognised, but little is known about patient outcomes. The objective of this study was to assess the outcomes of patients diagnosed with postcolonoscopy colorectal cancers (PCCRCs). We conducted a population-based retrospective cohort study, including all patients diagnosed with colorectal cancer (CRC) in Ontario, Canada from 2003 to 2009. Patients were categorised into three groups: DETECTED (diagnosed within 6 months of first colonoscopy), PCCRC (diagnosed 6-36 months after first colonoscopy) or NOSCOPE (no colonoscopy within 36 months of diagnosis). Univariate and multivariable analyses were conducted to study overall survival, surgical treatment, emergency presentation and surgical complications. Overall, 45 104 patients were included, with 2804 being classified as having a PCCRC. Compared with the DETECTED group, PCCRC was associated with a significantly higher likelihood of stage IV disease (17.2% vs 12.9%), worse overall survival (5 year OS: 60.8% vs 68.3%, p<0.0001; adjusted HR: 1.25, 95% CI 1.17 to 1.32, p<0.0001), a higher likelihood of emergency presentation (OR: 2.86, 95% CI 2.56 to 3.13, p<0.001) and lower likelihood of surgical resection ...Continue Reading

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Citations

Mar 22, 2016·Gastroenterología y hepatología·María Lourdes Ruiz-RebolloJosé Manuel González-Hernández
Apr 15, 2017·European Journal of Gastroenterology & Hepatology·Anna ForsbergRolf Hultcrantz
Mar 6, 2019·Digestive Diseases and Sciences·Wei-Ying ChenBor-Shyang Sheu
Mar 4, 2021·The American Journal of Gastroenterology·Aasma ShaukatDouglas K Rex
Oct 16, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Fahima DossaNancy N Baxter
May 30, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Frederikke S TroelsenRune Erichsen

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