Population-based case-control association studies

Current Protocols in Human Genetics
Dana B Hancock, William K Scott

Abstract

This unit provides an overview of the design and analysis of population-based case-control studies of genetic risk factors for complex disease. Considerations specific to genetic studies are emphasized. The unit reviews basic study designs, differentiating case-control studies from others, discusses selection of genetic markers for use in studies, introduces basic methods of analysis of case-control data, and discusses measures of association and impact. Controlling for confounding (including population stratification), consideration of multiple loci, and haplotype analysis are briefly discussed. Readers are referred to basic texts on epidemiology for more details on general conduct of case-control studies.

References

Sep 13, 1996·Science·N Risch, K Merikangas
Apr 29, 1998·BMJ : British Medical Journal·H T DaviesM Tavakoli
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Dec 29, 1998·American Journal of Human Genetics·D M NielsenB S Weir
Jun 8, 1999·Journal of the National Cancer Institute·J PetoM R Stratton
Sep 17, 1999·Bioinformatics·T A TatusovaJ A Ostell
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Jun 8, 2000·Bioinformatics·G R Abecasis, W O Cookson
Sep 27, 2000·Journal of Clinical Epidemiology·S D Walter
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Aug 30, 2001·Trends in Genetics : TIG·D E Reich, E S Lander
Oct 5, 2001·Nature Genetics·M J DalyE S Lander
Dec 26, 2001·Nucleic Acids Research·T HubbardM Clamp
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Jun 5, 2002·Genome Research·W James KentDavid Haussler
Jul 12, 2002·Nature·Elisabeth DawsonIan Dunham
Sep 28, 2002·Human Molecular Genetics·Desmond J Smith, Aldons J Lusis
Feb 13, 2003·American Journal of Epidemiology·James A HanleyJanet E Forrester
Mar 20, 2003·Journal of the National Cancer Institute·Gillian S DiteJohn L Hopper
May 20, 2003·Human Mutation·Peter D StensonDavid N Cooper
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Jun 9, 2004·Genetic Epidemiology·Weiwei ZhaiRasmus Nielsen
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Sep 15, 2004·Genome Research·Robert J LivingstonDeborah A Nickerson
Dec 31, 2004·American Journal of Human Genetics·Hua TangNeil J Risch
Feb 18, 2005·Nature Reviews. Genetics·Joel N Hirschhorn, Mark J Daly
Feb 18, 2005·Nature Reviews. Genetics·William Y S WangJohn A Todd
Mar 12, 2005·Science·Jonathan L HainesMargaret A Pericak-Vance
Apr 15, 2005·Mutation Research·Christopher Newton-Cheh, Joel N Hirschhorn
Jul 12, 2005·Human Genomics·Daniel O Stram
Aug 17, 2005·Human Molecular Genetics·Xiayi KeLon R Cardon
Sep 27, 2005·Lancet·Heather J Cordell, David G Clayton
Oct 11, 2005·Lancet·Andrew T Hattersley, Mark I McCarthy
Oct 18, 2005·Lancet·John L HopperDouglas F Easton
Feb 9, 2006·American Journal of Human Genetics·Jonathan MarchiniUNKNOWN International HapMap Consortium
Mar 15, 2006·PLoS Genetics·Alexandre MontpetitAndres Metspalu
Apr 12, 2006·Genetic Epidemiology·Hansong WangDaniel O Stram
Apr 19, 2006·Nature Reviews. Genetics·Nan M Laird, Christoph Lange

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