Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk

Pharmacogenetics and Genomics
Jirong LongWei Zheng

Abstract

The aryl hydrocarbon receptor (AhR) is a key regulator of the transcriptional expression for the cytochrome P450 1 (CYP1) genes. CYP1A2 is one of the major CYP1 enzymes that catalyse 2-hydroxylation of estrogen, a hormone that plays a critical role in the etiology of breast cancer. In this study, we investigated whether two common polymorphisms in these two genes, CYP1A2*1F and AhR Lys554Arg, were associated with breast cancer risk in 1090 cases and 1183 controls, a subset of the population-based case-control study, the Shanghai Breast Cancer Study. Caffeine tests were performed in vivo in a subset of 236 study subjects to investigate the relationship of these two polymorphisms with CYP1A2 activity. For the AhR gene, the A (Lys) allele was associated with a decreased risk of breast cancer. Using the genotype GG as reference, odds ratios of 0.82 [95% confidence interval (CI)=0.69-0.99] for the AG genotype and 0.76 (95% CI=0.58-1.01) for the AA genotype (P for trend=0.018) were obtained. However, no association was observed between CYP1A2 genotypes and breast cancer risk, although the CYP1A2*1F polymorphism was found to be related to CYP1A2 activity. The geometric mean values for the caffeine metabolites ratio were 2.90, 2.30, an...Continue Reading

References

Nov 1, 1991·Clinical Pharmacology and Therapeutics·W Kalow, B K Tang
Jun 1, 1995·Pharmacogenetics·K KawajiriS Hayashi
Oct 1, 1993·Pharmacogenetics·H I Swanson, C A Bradfield
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G Liehr, M J Ricci
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·Y T GaoW Zheng
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·L H KullerE N Meilahn
Jul 4, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·I Segal
Sep 22, 2001·The Journal of Steroid Biochemistry and Molecular Biology·R W BrueggemeierW E Burak
Sep 6, 2002·Chemico-biological Interactions·Patricia A HarperAllan B Okey
Nov 26, 2002·British Journal of Clinical Pharmacology·Anna NordmarkAnders Rane
Feb 18, 2003·Pharmacotherapy·Nehal J LakhaniWilliam D Figg
Apr 28, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Harald J J MoonenTheo M C M de Kok
Jun 8, 2004·Current Drug Metabolism·Jose A G Agundez
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Gertraud MaskarinecLoic Le Marchand
Mar 15, 2005·Toxicology Letters·Fabiola Castorena-TorresArnulfo Albores

❮ Previous
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Citations

Aug 13, 2008·Analytical and Bioanalytical Chemistry·Ulrich M ZangerMatthias Schwab
Sep 6, 2008·Nature Reviews. Cancer·Linda E KelemenCeline M Vachon
Apr 28, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aihua GuPeng Zhao
Feb 9, 2012·Molecular Pharmacology·Daniel P Dever, Lisa A Opanashuk
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aesun ShinWei Zheng
Dec 25, 2008·BMC Genomics·Kimberly L MahlerAmanda Ewart Toland
Sep 19, 2007·Genome Biology·Paul M Krzyzanowski, Miguel A Andrade-Navarro
Apr 11, 2009·World Journal of Gastroenterology : WJG·Tie-Li PengMin-Hu Chen
May 6, 2009·International Journal of Cancer. Journal International Du Cancer·Suleeporn SangrajrangTeruhiko Yoshida
Jun 18, 2015·Frontiers in Microbiology·P S S Rao, Santosh Kumar
Dec 5, 2014·Molecular Genetics and Genomics : MGG·Wen-Xia SunLin Zhang
Dec 28, 2017·Nutrition and Cancer·Idrees Ayoub ShahNazir Ahmad Dar
Feb 19, 2011·Genetic Testing and Molecular Biomarkers·Virendra SinghMahendra Pratap Singh
Apr 13, 2007·Pharmacogenetics and Genomics·Ji-Rong LongWei Zheng
Nov 7, 2012·Molecular Medicine Reports·Imene AyariSofia Pavanello
Apr 30, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ayari ImeneSaguem Saad

❮ Previous
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