Population-based case-control study of oxoline acid use during pregnancy for birth outcomes

Congenital Anomalies
István DudásA E Czeizel

Abstract

The objective of the study was to check the effect of oxoline acid, a bactericidal drug for the treatment of urinary tract infection during pregnancy, on congenital abnormalities of informative offspring and fetal development. Human data of oxoline acid use during pregnancy have not been reported, but the use of this quinolone derivative is not recommended during pregnancy by the US Food and Drug Administration. The teratogenic and fetotoxic potential of oxoline acid was evaluated in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996. Observed and expected numbers of congenital abnormalities were compared in the newborn infants and fetus of case mothers with oxoline acid treatment. In addition, gestational age and birthweight were evaluated in control newborn infants born to mothers with or without oxoline acid treatment. Of 38,151 newborn infants without any congenital abnormalities (control group), 13 (0.03%) had mothers who were treated with oxoline acid, while of 22,843 cases with congenital abnormalities, five (0.02%) had mothers who were treated with oxoline acid during pregnancy (POR with 95% CI: 0.6, 0.2-1.8). The comparison of observed and ex...Continue Reading

References

May 30, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A E CzeizelJ Olsen
May 1, 2002·Pharmacoepidemiology and Drug Safety·A E Czeizel
Aug 6, 2003·Pharmacoepidemiology and Drug Safety·A E CzeizelP Vargha

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Citations

Feb 3, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Benjamin Bar-OzGideon Koren
Apr 25, 2012·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·James L SchardeinBjorn A Thorsrud
Nov 20, 2014·Obstetrical & Gynecological Survey·Enav YefetZohar Nachum
Jan 11, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·E YefetZ Nachum

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