Population based epidemiology and prognosis of mesothelioma in Leeds, UK

Thorax
A ChapmanMartin F Muers

Abstract

Malignant mesothelioma is a fatal neoplasm, which is rapidly increasing in incidence throughout Western Europe. To date there have been no studies reporting on the natural history and interventional practices on a comprehensive unselected population, as opposed to reports from referral institutions or compensation claimants. We present a population based study capturing data on all patients with mesothelioma presenting within a defined geographical area over a 4 year period in the UK. Data of all cases occurring in Leeds with a population of 750 000 were collected retrospectively from 2002 to 2003 and prospectively from 2004 to 2005. All patients' hospital records and the Trust histology database were reviewed, as well as coroner's reports on all patients with a post mortem diagnosis of mesothelioma. Over the 4 year study period, there were a total of 146 cases in Leeds; 77% were male. Median age was 74 years (range 36-93). Median survival from diagnosis was 8.9 months. 92% and 8% had histological or cytological confirmation, respectively. 85% had documented evidence of definite or probable exposure to asbestos. 110/146 (75%) had symptomatic pleural effusions at presentation. Twice the number of patients (42 vs 17) were managed...Continue Reading

Citations

Sep 21, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·S MurphyK Sridharan
Jan 6, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Apostolos NakasDavid Waller
Jan 27, 2009·BMC Cancer·Catherine OkelloHenrik Møller
Mar 28, 2012·AJR. American Journal of Roentgenology·Carlos A RojasJonathan H Chung
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology·Anna L HansellLesley Rushton
Feb 26, 2011·Expert Review of Respiratory Medicine·Joseph S Friedberg
Feb 6, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nicholas MacLeodBarry J Laird
Jan 8, 2014·Cancer Epidemiology·Cormac J JenningsWarren Thomas
Mar 31, 2012·Critical Reviews in Oncology/hematology·Anthony LintonNico van Zandwijk
Sep 23, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Beth WoodsNicholas Thatcher
Jul 25, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Caroline LeeCorinne Faivre-Finn
Nov 14, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Christopher W LeeWinston Bishop
Dec 8, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Annabel J SharkeyDavid A Waller
Sep 16, 2008·International Journal of Cancer. Journal International Du Cancer·Fabio MontanaroDario Mirabelli
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Chun WanFu-Qiang Wen
Oct 11, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marie-Anne FromentAnne Dagnault
Dec 10, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·N MacleodB Laird
Mar 5, 2010·International Journal of Health Services : Planning, Administration, Evaluation·Philip BohleMichael Quinlan
May 25, 2016·Diagnostic Cytopathology·Kazuki NabeshimaKunimitsu Kawahara
Aug 21, 2016·Occupational and Environmental Medicine·P FranklinA W Musk
Apr 21, 2017·Current Opinion in Pulmonary Medicine·David T Arnold, Amelia O Clive
Mar 29, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil BaymanCorinne Faivre-Finn
May 31, 2012·British Journal of Cancer·S van der BijK G M Moons
Feb 9, 2017·British Journal of Cancer·David T ArnoldNick A Maskell
Jul 17, 2015·BJR Case Reports·S L Savaridas, G D Bristow
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.