Population-Based Evaluation of Major Adverse Events After Catheter Ablation for Atrial Fibrillation

JACC. Clinical Electrophysiology
Michelle SamuelVidal Essebag

Abstract

The purpose of this study was to evaluate the safety and incidence of periprocedural adverse events (AEs) among patients who underwent catheter ablation (CA) for atrial fibrillation (AF) in Quebec and Ontario, Canada. CA is evolving into the mainstay therapy for patients with symptomatic AF refractory to antiarrhythmic medication. However, the safety of CA at the population level over time requires further evaluation. A population-based cohort was constructed using administrative databases of all patients who underwent CA between 1999 and 2014 in Quebec and Ontario, Canada. Incidence and predictors of AEs were assessed within 30 days of CA. Major AEs included all-cause mortality, cerebrovascular accident (CVA) including transient ischemic attack, pericardial effusion requiring drainage (PERD), vascular AEs, hemorrhage/hematoma, and pulmonary embolism. Of 6,388 patients who had a CA (mean age 57.3 years; mean CHA2DS2-VASc 1.1 ± 1.4; 27.6% female), 221 (3.5%) patients developed major AEs within 30 days of index CA. Hemorrhage/hematoma was the most frequent (1.4%), followed by PERD (1.0%) and CVA (0.6%). PERD was more likely to occur post-discharge than during the index CA (p < 0.05). CVA decreased by more than 50% in patients wit...Continue Reading

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Citations

Oct 4, 2019·Journal of Cardiovascular Electrophysiology·Michelle SamuelVidal Essebag
Jan 25, 2020·Journal of Cardiovascular Electrophysiology·Kavisha Patel, Luigi Di Biase
Apr 1, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michelle SamuelLouise Pilote
Apr 5, 2021·Pacing and Clinical Electrophysiology : PACE·Csaba FöldesiKyoung Ryul Julian Chun
May 9, 2021·European Heart Journal. Quality of Care & Clinical Outcomes·Linh NgoIsuru Ranasinghe

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