Population-Based Patterns of Surgical Care for Stage IIIA NSCLC in the Netherlands between 2010 and 2013

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
C DickhoffR A Damhuis

Abstract

Current guidelines include both induction therapy plus an operation and chemoradiotherapy (CRT) as options for clinical stage IIIA (cIIIA) non-small cell lung cancer (NSCLC) after multidisciplinary evaluation. We explored the use of operations for cIIIA NSCLC in the Netherlands. Data about the primary treatment of patients with cIIIA NSCLC (according to the seventh edition of the Tumour, Node, and Metastasis Classification of Malignant Tumours) between 2010 and 2013 were extracted from the Netherlands Cancer Registry. Mortality information was obtained from the automated civil registry. A total of 4816 patients with cIIIA NSCLC (stage cN2, 3240 [67%]; stage T4, 1252 [26%]) were identified. CRT was used in 45% of patients and an operation was a component of treatment in 15%, with 28% of the latter having induction therapy. The 4-year survival rate was highest with induction therapy plus an operation (51%), followed by an operation plus adjuvant therapy (39%) and CRT (27%). Patients receiving induction therapy plus an operation were younger than those receiving CRT (median age 60 versus 66 years). The 30- and 90-day postoperative mortality rates after induction therapy plus lobectomy were 0.6% and 3.7% compared with 4.2% and 12.5...Continue Reading

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Citations

Oct 1, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C DickhoffM Dahele
Oct 31, 2017·Therapeutic Advances in Medical Oncology·David J HeinemanWilhelmina H Schreurs
Jan 9, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Merle I RondenSuresh Senan
Oct 4, 2020·The European Respiratory Journal·Jelle E BousemaFrank J C van den Broek
Jun 8, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jolanda C KuijvenhovenJouke T Annema
Jan 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C DickhoffM Dahele

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