Population-Based Prevalence of Chlamydia trachomatis Infection and Antibodies in Four Districts with Varying Levels of Trachoma Endemicity in Amhara, Ethiopia.

The American Journal of Tropical Medicine and Hygiene
Scott D NashDiana L Martin

Abstract

The Trachoma Control Program in Amhara region, Ethiopia, scaled up the surgery, antibiotics, facial cleanliness, and environmental improvement (SAFE) strategy in all districts starting in 2007. Despite these efforts, many districts still require additional years of SAFE. In 2017, four districts were selected for the assessment of antibody responses against Chlamydia trachomatis antigens and C. trachomatis infection to better understand transmission. Districts with differing endemicity were chosen, whereby one had a previous trachomatous inflammation-follicular (TF) prevalence of ≥ 30% (Andabet), one had a prevalence between 10% and 29.9% (Dera), one had a prevalence between 5% and 10% (Woreta town), and one had a previous TF prevalence of < 5% (Alefa) and had not received antibiotic intervention for 2 years. Survey teams assessed trachoma clinical signs and took conjunctival swabs and dried blood spots (DBS) to measure infection and antibody responses. Trachomatous inflammation-follicular prevalence among children aged 1-9 years was 37.0% (95% CI: 31.1-43.3) for Andabet, 14.7% (95% CI: 10.0-20.5) for Dera, and < 5% for Woreta town and Alefa. Chlamydia trachomatis infection was only detected in Andabet (11.3%). Within these dist...Continue Reading

References

Jan 1, 1995·Lifetime Data Analysis·N P Jewell, M V Laan
Mar 20, 2008·PLoS Neglected Tropical Diseases·Paul M EmersonFrank O Richards
Sep 30, 2008·PLoS Neglected Tropical Diseases·Jonathan D KingPaul M Emerson
Jun 23, 2011·Investigative Ophthalmology & Visual Science·Matthew J BurtonRobin L Bailey
Nov 8, 2012·PLoS Neglected Tropical Diseases·E Brook GoodhewPatrick J Lammie
Mar 15, 2014·PLoS Neglected Tropical Diseases·Jonathan D KingPaul M Emerson
Apr 24, 2014·BMC Infectious Diseases·Erica Brook GoodhewDiana L Martin
Feb 26, 2015·PLoS Neglected Tropical Diseases·Diana L MartinAnthony W Solomon
Jul 15, 2015·Ophthalmic Epidemiology·Anthony W SolomonAllen Foster
Dec 22, 2015·Scientific Reports·Diana L MartinManoj Gambhir
Feb 13, 2016·PLoS Neglected Tropical Diseases·Bidya Prasad PantBruce D Gaynor
Oct 27, 2016·PLoS Neglected Tropical Diseases·Athumani M RamadhaniMatthew J Burton
Nov 10, 2017·Scientific Reports·Stephanie J MigchelsenChrissy H Roberts
Dec 24, 2018·Nature Communications·Amy PinsentMichael T White
Sep 25, 2019·The American Journal of Tropical Medicine and Hygiene·Aisha E P StewartScott D Nash
Oct 10, 2019·The American Journal of Tropical Medicine and Hygiene·Catherine E Oldenburg
Sep 25, 2020·PLoS Neglected Tropical Diseases·Diana L MartinAnthony W Solomon

❮ Previous
Next ❯

Citations

Jul 30, 2021·Diagnostic Microbiology and Infectious Disease·Damien C DanavallBrian H Raphael

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleic acid amplification
MDA

Software Mentioned

Tropical Data
Bio
Stata
Plex Manager
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.