Abstract
There are conflicting studies of the impact of androgen deprivation therapy (ADT) on cardiovascular (CV) mortality among prostate cancer patients receiving curative intent external beam radiation therapy (EBRT). We assessed the impact of ADT on CV mortality in patients treated in British Columbia. Provincial pharmacy and radiotherapy databases were linked to the provincial cancer registry, and defined a cohort of patients treated with curative intent EBRT between 1998 and 2005. We determined the duration of ADT and the cumulative incidence of CV death. We compared death from CV disease with and without ADT, and by duration of ADT using competing risk analysis and Fine and Gray multivariant analysis. A total of 600 randomly selected patients were reviewed to determine baseline CV disease, CV risk factors, and Charlson Index. Of 5,948 prostate cancer patients treated with radical intent EBRT, of whom 1,933 were treated without ADT, 674 received ADT for ≤ 6 months and 3,341 received > 6 months of ADT. The cumulative CV mortality at 7 years was 2.6% (95% confidence interval [CI] 1.9-3.5%), 2.1% (95% CI = 1.2-3.5%), and 1.4 (95% CI = 1.0-2.0%) for patients with no ADT, ≤ 6 months of ADT, and >6 months of ADT, respectively (Gray's p ...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Jul 20, 2002·Lancet·Michel BollaMarianne Pierart
Aug 19, 2004·JAMA : the Journal of the American Medical Association·Anthony V D'AmicoPhilip W Kantoff
May 5, 2005·JAMA : the Journal of the American Medical Association·Peter C AlbertsenJudith Fine
Aug 2, 2006·BJU International·Michael J BarryDavid C Wennberg
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Milena Braga-BasariaShehzad Basaria
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
Jun 15, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony V D'AmicoPhilip W Kantoff
Jul 28, 2007·Cancer·Christopher S SaigalUNKNOWN Urologic Diseases in America Project
Oct 11, 2007·Journal of the National Cancer Institute·Henry K TsaiPeter R Carroll
Jan 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mack RoachMiljenko V Pilepich
Feb 5, 2008·European Urology·Jason A EfstathiouMatthew R Smith
Feb 5, 2008·European Urology·Peter Whelan
Mar 19, 2008·Cancer·Matthew R SmithJoel S Finkelstein
Jun 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shabbir M H AlibhaiLawrence F Paszat
Jun 12, 2009·The New England Journal of Medicine·Michel BollaUNKNOWN EORTC Radiation Oncology Group and Genito-Urinary Tract Cancer Group
Aug 27, 2009·JAMA : the Journal of the American Medical Association·Akash NandaAnthony V D'Amico
May 11, 2011·Statistics in Medicine·Xu ZhangJason Fine
Citations
Feb 22, 2012·Asian Journal of Andrology·Lauren Collins, Shehzad Basaria
Sep 4, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A ZapateroX Maldonado
Dec 9, 2014·European Urology·Cecilia BoscoMieke Van Hemelrijck
Aug 25, 2015·Journal of Oncology·Margot K DavisSean A Virani
Sep 30, 2014·PloS One·Jinsheng ZhaoYuanjie Niu
Jun 28, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I LatorzeffA Pathak
May 18, 2016·Journal of Diabetes Investigation·Huimin WangJinsheng Zhao
Feb 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm D MasonPadraig Warde
Jan 15, 2013·Emergency Medicine Journal : EMJ·Sandrine Hegg-DeloyePhilippe Corbeil
Jun 3, 2017·Medical Oncology·Pawel J WiechnoTomasz Demkow
Oct 19, 2020·Brachytherapy·Shinya SutaniShiro Saito