Population-based study of patients with primary Sjögren's syndrome and lymphoma: lymphoma subtypes, clinical characteristics, and gender differences

Scandinavian Journal of Rheumatology
L VasaitisEva Baecklund

Abstract

Objective: To examine lymphoma subtypes, clinical characteristics, and gender differences in patients with primary Sjögren's syndrome (pSS) and lymphoma in a population-based setting.Method: Patients with Sjögren's syndrome and lymphoma diagnoses were identified by linkage of the Swedish Patient Register 1964-2007 with the Cancer Register 1990-2007. Clinical data were collected from medical records and lymphoma tissues were re-examined. The lymphoma subtype distribution was compared with the Swedish Lymphoma Register.Results: We identified 105 pSS patients with lymphoma. Diffuse large B-cell lymphoma (DLBCL) (32%) and marginal zone lymphoma [MZL including mucosa-associated lymphoid tissue (MALT) lymphoma] (31%) were the most common lymphoma subtypes. The proportion of DLBCL was not increased compared to the general population reference (32%, p = 1), in contrast to MZL (general population 5%, p < 0.0001). Compared to DLBCL, MALT lymphoma was diagnosed at a younger age (55 vs 67 years, p = 0.0001), and earlier after patient-reported sicca onset (7 vs 18 years, p = 0.0001) and pSS diagnosis (2 vs 9 years, p = 0.0005). Sixteen of the pSS-lymphoma cases were men (15%), twice the proportion in general pSS populations. Compared to wom...Continue Reading

References

Dec 1, 1978·Annals of Internal Medicine·S S KassanT M Chused
Nov 7, 1998·Seminars in Arthritis and Rheumatism·N SutcliffeD Isenberg
Mar 29, 2002·Arthritis and Rheumatism·John P A IoannidisHaralampos M Moutsopoulos
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Jan 5, 2006·Journal of the National Cancer Institute·Karin Ekström SmedbyHans-Olov Adami
Nov 30, 2006·Arthritis and Rheumatism·Eva BaecklundRichard Rosenquist
Jul 10, 2008·Scandinavian Journal of Rheumatology·G GondranE Vidal
Jun 30, 2009·Annals of the Rheumatic Diseases·Raphaèle SerorUNKNOWN EULAR Sjögren's Task Force
Sep 21, 2010·International Journal of Cancer. Journal International Du Cancer·Pat AnsellEve Roman
Jun 15, 2011·Seminars in Arthritis and Rheumatism·Roser Solans-LaquéMiquel Vilardell-Tarres
Dec 27, 2011·Medicine·Michael VoulgarelisHaralampos M Moutsopoulos
Jul 5, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Theodoros N SergentanisEleni Th Petridou
Nov 10, 2012·Arthritis Care & Research·Svein J JohnsenRoald Omdal
May 15, 2013·Seminars in Arthritis and Rheumatism·Anna P RisseladaJohannes W J Bijlsma
Dec 18, 2013·Seminars in Cancer Biology·Eva BaecklundRichard Rosenquist
Aug 2, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M FallahK Hemminki
Sep 9, 2015·American Journal of Epidemiology·Peter HollanderHenrik Hjalgrim
Jun 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Thomas FlamentSylvain Marchand-Adam
Jun 24, 2016·Medicine·Sofia FragkioudakiHaralampos M Moutsopoulos
Jul 8, 2016·Nature Reviews. Disease Primers·Pilar Brito-ZerónManuel Ramos-Casals
Aug 10, 2017·Biology of Sex Differences·Jorge I Ramírez SepúlvedaMarie Wahren-Herlenius
Nov 14, 2018·Scandinavian Journal of Rheumatology·L VasaitisE Baecklund

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Aug 20, 2020·American Journal of Clinical Dermatology·Roberto MaglieEmiliano Antiga
Dec 17, 2020·Journal of Clinical Medicine·Giuseppe IngravalloSaverio Capodiferro

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