PMID: 9169400May 31, 1997Paper

Population based study of prevalence of islet cell autoantibodies in monozygotic and dizygotic Danish twin pairs with insulin dependent diabetes mellitus

BMJ : British Medical Journal
J S PetersenH Beck-Nielsen

Abstract

To study the comparative importance of environment and genes in the development of islet cell autoimmunity associated with insulin dependent diabetes mellitus. Population based study of diabetic twins. Danish population. 18 monozygotic and 36 dizygotic twin pairs with one or both partners having insulin dependent diabetes. Presence of islet cell antibodies, insulin autoantibodies, and autoantibodies to glutamic acid decarboxylase (GAD65) in serum samples from twin pairs 10 years (range 0-30 years) and 9.5 years (2-30 years) after onset of disease. In those with diabetes the prevalence of islet cell antibodies, insulin autoantibodies, and autoantibodies to glutamic acid decarboxylase in the 26 monozygotic twins was 38%, 85%, and 92%, respectively, and in the dizygotic twins was 57%, 70%, and 57%, respectively. In those without diabetes the proportions were 20%, 50%, and 40% in the 10 monozygotic twins and 26%, 49%, and 40% in the 35 dizygotic twins. There is no difference between the prevalence of islet cell autoantibodies in dizygotic and monozygotic twins without diabetes, suggesting that islet cell autoimmunity is environmentally rather than genetically determined. Furthermore, the prevalence of islet cell antibodies was high...Continue Reading

Citations

Oct 27, 2001·BMJ : British Medical Journal·E A GaleJ S Petersen
Jul 25, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·A Galli-Tsinopoulou, S Nousia-Arvanitakis
Jun 8, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·T Kimpimäki, M Knip
Aug 2, 2013·International Journal of Biological Sciences·Yan-Ling WuWen Zhang
Mar 20, 2003·Current Diabetes Reports·Anu-Maaria Hämäläinen, Mikael Knip
Aug 2, 2007·Journal of Pediatric Gastroenterology and Nutrition·Serena Ballotti, Maurizio de Martino
Jul 13, 2002·American Journal of Medical Genetics·Mohammed Iqbal HawaRichard David Graham Leslie
Dec 4, 2003·Diabetes/metabolism Research and Reviews·Ruben Varela-Calvino, Mark Peakman
Jun 30, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V Bonnevie-NielsenT Dyrberg
Feb 25, 2017·Epidemiology and Health·Aziz RezapourSajad Vahedi
Dec 6, 2003·Pediatric Diabetes·Joel N Hirschhorn
Apr 4, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·K O KyvikK Buschard
Apr 28, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·I C West
Apr 4, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·G R LawP A McKinney
Jun 11, 1999·Diabetes/metabolism Research and Reviews·S Muntoni, S Muntoni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.